Science - USA (2022-01-14)

120 14 JANUARY 2022 • VOL 375 ISSUE 6577 science.org SCIENCE

IMAGE: ALEX HALL AND MEGAN MAYER

205 2D materials

Crossover between strongly coupled and

weakly coupled exciton superfluids

X. Liu et al.

210 Ecology

The effects of defaunation on plants’

capacity to track climate change

E. C. Fricke et al.

214 Atherosclerosis

Olfactory receptor 2 in vascular macrophages

drives atherosclerosis by NLRP3-dependent

IL-1 production M. Orecchioni et al.

PERSPECTIVE p. 145

221 Cell biology

Bacterial gasdermins reveal an ancient

mechanism of cell death A. G. Johnson et al.

226 Physics

Observation of a gravitational

Aharonov-Bohm effect C. Overstreet et al.

PERSPECTIVE p. 142

ON THE COVER

A blue-throated barbet (Psilopogon asiaticus)

eats a fig in southern Bhutan, dispersing

the seeds within. Seed-dispersing animals

help fleshy-fruited plants adapt to climate

change by moving seeds to suitable habitats.

However, many seed dispersers are in decline,

endangered, or extinct.

Bird and mammal

population losses have

caused an estimated

60% decline in seed

dispersal, limiting plants’

ability to track climate

change. See page 210.

Photo: Christian Ziegler

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CONTENTS

DEPARTMENTS

121 Editorial

When hyping technology is a crime

By H. Holden Thorp

123 Editorial

Lessons learned from leading NIH

By Francis S. Collins

234 Working Life

No need to hide

By Anderson Eduardo-Santos

Science Staff .............................................. 122

New Products ............................................. 231

Science Careers .........................................

Membrane pores are

formed by bacterial gasdermin

221

RESEARCH

IN BRIEF

155 From Science and other journals

REVIEW

158 Cancer
CDK4 and CDK6 kinases: From basic science
to cancer therapy A. Fassl et al.
REVIEW SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABC

RESEARCH ARTICLES

159 Cell biology
Mitochondria shed their outer membrane
in response to infection-induced stress
X. Li et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABI

160 Coronavirus
Impact of community masking on COVID-19:
A cluster-randomized trial in Bangladesh
J. Abaluck et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABI

153 Central nervous system weapons
dealt a blow
By M. Crowley and M. Dando

154 Transboundary conservation’s rise
By J. Liu et al.

154 Technical Comment abstracts

161 Coronavirus

4′-Fluorouridine is an oral antiviral that

blocks respiratory syncytial virus and

SARS-CoV-2 replication J. Sourimant et al.

167 Neurodegeneration

Cryo-EM structures of amyloid-b 42

filaments from human brains Y. Yang et al.

PERSPECTIVE p. 147

172 Martian geology

Organic synthesis associated with

serpentinization and carbonation on

early Mars A. Steele et al.

177 Plant science

An RNA exosome subunit mediates

cell-to-cell trafficking of a homeobox mRNA

via plasmodesmata M. Kitagawa et al.

183 Coronavirus

Heterologous infection and vaccination

shapes immunity against SARS-CoV-

variants C. J. Reynolds et al.

REPORTS

193 Topological matter

Distinguishing between non-abelian topological

orders in a quantum Hall system B. Dutta et al.

198 Molecular magnets

Ultrahard magnetism from mixed-valence

dilanthanide complexes with metal-metal

bonding C. A. Gould et al.

202 Planetary science

Measuring the melting curve of iron at

super-Earth core conditions R. G. Kraus et al.

PERSPECTIVE p. 146; PODCAST

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