Science - USA (2022-01-21)

SCIENCE science.org/custom-publishing 21 JANUARY 2022 • VOL 375 ISSUE 6578 347

Produced by the Science/AAAS Custom Publishing Office LIFE SCIENCE TECHNOLOGIES

new products: COVID-19

COVID -19 Omicron Variant

Research Tools

AMS Biotechnology (AMSBIO)

announces new additions to its

portfolio of tools for COVID-19

research. AMSBIOís Spike-

neutralizing monoclonal antibodies

(clone G10xA5 and G10xA1)

recognize the SARS-CoV-2 Spike receptor-binding domain (RBD)

(B.1.1.529, Omicron variant) protein and neutralize its interaction

with angiotensin-converting enzyme 2 (ACE2). Also new is

AMSBIOís Spike S1 RBD: ACE2 Inhibitor Screening Assay Kit. This









   





inhibitors or neutralizing antibodies of the interaction between the

Omicron variant SARS-CoV-2 Spike RBD and human ACE2. AMSBIO







    

































of antibodies and vaccines.

AMS Biotechnology

For info: +1-617-945-5033

http://www.amsbio.com/sars-cov-2-spike-mutants

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this

space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not

implied. Additional information may be obtained from the manufacturer or supplier.

Electronically submit your new product description or product literature information! Go to http://www.science.org/about/new-products-section for more information.

SARS-CoV-2 Variant Neutralization Antibody Assays

Bio-Rad Laboratories has released Bio-Plex Pro Human SARS-CoV-2

Variant Neutralization Antibody Assays, for research use only (RUO).

The assays allow scientists to measure neutralizing antibodies quickly





    

 

CoV-2 virus. Scientists developing vaccines and therapeutics can



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clinical phases. Epidemiologists can perform seroprevalence studies

to better understand the longevity of the neutralizing antibody

response from infection or vaccination. Researchers can increase

their throughput when using the multiplex Bio-Plex Pro Assays, as

compared to traditional cell-based assays and ELISA tests. The assays

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of the wild-type RBD and S1 and 9 variant antigens, as well as

customizable singleplex assays, 2-plex Delta variant coupled beads,

and a custom Assay Developer Kit to create assays to any new SARS-

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Bio-Rad Laboratories

F or info: +1- 8 0 0 - 424 - 67 2 3

bio-rad.com/nabsarscov2

Fluorescent-Labeled Spike Proteins



    



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feature Alexa Fluor dyes, which easily detect ACE2 expression on



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antigen receptor (CAR) on CAR T cells or other cell types of interest.

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labeling, and the resulting Fluorokines are rigorously tested to

ensure consistent labeling of each lot. The entire manufacturing

process is controlled to reduce lot-to-lot variability and delivers a



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R&D Systems

F or info: +1- 8 0 0 -3 4 3 -7475

http://www.rndsystems.com

T-Cell Tests

Hyris partnered with prestigious academic and research teams

to develop rapid T-cell tests to track patient immunity levels to

 





    



    

responses in COVID-19-inoculated or convalescent patients, as well

as measuring individual immunity levels for vaccinated people.

The solution leverages the portability and reliability of the Hyris

System, allowing deployment of T-cell testing anywhere, any time,

with real-time results available immediately through Hyris dedicated

software. The system deploys reverse transcription PCR technology,

the ìgold standardî according to the U.S. Centers for Disease Control












testing guidelines. At the core of the system is the HYRIS bCUBE,

a miniaturized, state-of-the-art device for nucleic acid analysis.

With ultracompact instrument design and superior analytical

performance, the Hyris bCUBE has direct connectivity to the

p r o p r i e t a r y H Y R I S b A P P.

Hyris

For info: +44-(0)-2039361227

http://www.hyris.net/index.php/t-cell

ELISA Kits for SARS-CoV-2



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sandwich ELISA kits for detecting immunoglobulins against SARS-

CoV-2 proteins and the cytokines involved in cytokine release

syndrome. These kits are developed and validated to detect

immunoglobulin G and immunoglobulin M immunoglobulins against

the RBD of SARS-CoV-2 Spike protein (S protein) and Nucleocapsid

 

   !

ELISA kits are extensively validated using in-house developed,

human cellñexpressed cytokines. Emerging evidence suggests that

hyperactivity of the immune system after SARS-CoV-2 infection can

trigger excessive release of cytokines such as IL-6, TNF alpha, and

IFN gamma. This rapid immune escalation is called the ìcytokine

storm syndromeî and can lead to severe lung damage and death.

Proteintech

For info: +1-888-478-4522

http://www.ptglab.com

SARS-CoV-2 PCR Products and Services

PCR Biosystems is committed to providing researchers, developers,

and diagnostic kit manufacturers with the PCR products and

services they need in the global response to COVID-19. We have

massively increased manufacture of critical reagents for rapid

and sensitive reverse transcription quantitative PCR (RT-qPCR).

We manufacture under a rigorous ISO 9001 and ISO 13485 quality


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introduced 50-mL and 500-mL bulk sizes of our RT-qPCR mixes into

our standard portfolio to provide greater consistency, convenience,

and value in COVID-19 testing. With over 180 years of combined

PCR experience on our team, we can optimize assay conditions and

 









PCR Biosystems

For info: +44-(0)-20-3930-8101

pcrbio.com/usa/produc t s/covid-19

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