CAR-T Cells Via mRNA Transfection
Chimeric Antigen Receptors Encoded by mRNA
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Allproductsareforresearchonly2600 Hilltop Dr, Building B, Suite C320, Richmond, CA 948061.866.339.0871 | [email protected]RNA encoding CAR is
delivered to T cells Protein is translated
from RNA
CAR-T receptor
expressed on the
T cell surfaceUtilizing mRNA electroporation, rather than viral transduction, to achieve expression of
the CAR has become a widely researched topic in alternative solutions to gene delivery
in CAR-T cell therapy. Transient CAR-T cells offer several distinct advantages over
autologous, virally transduced CAR-T cells, including decreased risk of toxicity due to a
shorter half-life, and a cheaper, less labor-intensive gene transfer procedure.
At ProMab, we can synthesize any mRNA sequence and transiently express it in T cells.
We provide multiple means of validation with our comprehensive cell-based assay
services, such as FACS and real-time cell analysis (RTCA), with downstream options for in
vivo analysis. Check out our platform to see how we can develop your CAR-T cells.
CAR-T Production Services
RNA encoding CAR is
delivered to T cells Protein is translated
from RNA
CAR-T receptor
expressed on the
T cell surfaceRNA encoding CAR is
delivered to T cells Protein is translated
from RNA
CAR-T receptor
expressed on the
T cell surface0121Product.indd 352 1/12/22 7:26 AM