basic features of, 392–394
case-control studies, 392–409
category matching, 393–394
cohort studies, 409–413
confidence intervals, 393
exchangeability and, 407–408
follow-up data, 409–413
interaction and, 404–406
logistic model and, 397–400
major disadvantage, 394
matching factors, 392
ML estimation and, 401
pooling, 407–409
precision and, 393
stratification, 394–397
validity and, 394
Mathematical models, 5
Matrix algebra, 117–118, 132–133,
507, 524
Maximum likelihood (ML) methods,
106–107
numerical example, 147–153
overview, 106
statistical inferences using, 130–153
subject-specific saturated model, 312
unconditionalversusconditional,
107–109
McNemar test, 396–397, 412
Meaningful change in OR,
concept of, 217
Methicillin-resistance infection (MRSA)
example, 244
Method 0, 265–270
MI dataset, 600
Mixed logistic model (MLM),
580, 584
ML.SeeMaximum likelihood methods
MLM.SeeMixed logistic model
Modeling strategy
confounding and, 203–230
example of, 188–192
guidelines for, 165–192
interaction and, 203–230
overview of, 169–173
rationale for, 168–169
several exposure variables, 244–262
Moderate samples, 121
MOR.SeeMantel–Haenszel odds ratio
Multicollinearity, 172, 280
Multilevel outcomes, 432
Multiple linear regression, 169
Multiple standard logistic regressions,
453, 479–481
Multiple testing, 172
Multiplicative interaction, 49–53
Multivariable problem, 4–5
N
No interaction model, 63, 78–79, 83–85,
149–150, 152–153, 211–215
Nominal exposure variable, 82–84
Normal distribution, 141
Nuisance parameters, 116, 526, 575
Null hypotheses, 54, 280
O
Odds, 18–19
Odds ratio (OR), 11–13
adjusted, 26, 27, 77
computation of, 25–26, 64, 74–91
confidence limits, 141, 472–475
confounders and, 87–91, 221
correlation measure and, 571
examples of, 22–23
exchangeable, 573
as fixed, 60, 79
formula for, 22–25, 84
invariance of, 468
logistic regression and, 74–91
MOR and, 396
risk ratio and, 15–16
three categories, 437–441
One-to-one matching, 393
OR.SeeOdds ratio
Ordinal logistic regression, 466–472
SAS and, 620–621
SPSS and, 644–646
Stata and, 658
Ordinal models, 466–472
Ordinal variables, 79
P
Pair matching, 110–111, 393–398,
400–403
Parameterizing, of model, 470
Parameters, number of, 108
Pearson statistic, 322
Perfect fit, 305
Index 699