Organic Chemistry of Drug Synthesis. Volume 7
(DBU) flowed by methyl iodide leads to the corresponding methyl ester 11. Heating 11 with ethylamine leads to ester interchange ...
of this aldehyde with the ylide from the difluorinated phosphonate 14 leads to the addition product 15. The double bond in thef ...
by its trade name Tamiflu, has focused considerable attention on this drug. A significant amount of work has been devoted to its ...
Sodium azide again opens a strained reactive three-membered ring. There is thus obtained the acetamido azide ( 33 ). Repeat of t ...
CO 2 C 2 H 5 NH 2 AcHN O 34 CO 2 CH 2 CF 3 + 35 NBO C (^6) HH (^5) C 6 H 5 H (^36) CO 2 CH 2 CF 3 37 NH 3 CO 2 NH 2 38 I 2 HN I ...
HN O 46 (t-BuOCO) 2 O CH 3 OH t-BOCNH CO 2 CH 3 47 NO 2 t-BOCNH CO 2 CH 3 NO N OH 48 49 H 2 Ac 2 O tBOCNH CO 2 CH 3 NHAcOH ...
to the ring of a carbon atom at the acid oxidation stage. Oxidation of the sulfur atoms in this intermediate with mercuric chlor ...
CO 2 H 62 CO 2 CH 3 63 LiAlH 4 2. MnO 2 CH=O 64 CO 2 C 2 H 5 (C 2 H 5 O) 2 P O 66 ; R = C 2 H 5 67 ; R = H CO 2 R 65 NaH 2. PO ...
route from this point on is speculative as details are not readily accessible. Reaction of this last literature intermediate ( 7 ...
gonane, with hydrogen peroxide, results in selective reaction at the 5,10 double bond to give the epoxide 78. The proximity of t ...
The purified isomer ( 84 )^14 is currently used in the clinic as a treatment for endometriosis, as well as other conditions rela ...
growth of those new blood vessels thus saving still-intact areas the retina. The sequence for preparation of the agent begins wi ...
long been indicated for treating asthma. It has recently been found that the acetal containing cylcohexane carboxaldehyde penetr ...
opened to the corresponding keto acid ( 102 ) by oxidation of the double bond in ring A by means of permanganate. Reaction of th ...
group is next converted to the activated imidazolide by reaction with carbonyl diimidazole. Condensation of this intermediate wi ...
adds to the last open position of the extended eneone system. Thus, 114 is obtained.^23 HO O OH OH 112 H 2 SO 4 HO O 113 HO O OH ...
Reduction of this intermediate by hydrogen transfer from 1,4-cyclohexa- diene in the presence of platinum leads to loss of the c ...
R. Hesse, U.S. Patent 4,772,433 (1988). R.H. Hesse, G.S. Reddy, S.K.S. Setty, U.S. Patent 5,494,905 (1996). T.C. McMorris, Y. H ...
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CHAPTER 3 3 MONOCYCLIC AROMATIC COMPOUNDS COMPOUNDS Free-standing benzene rings have provided the core for a very large number o ...
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