Science - USA (2022-02-04)

472 4 FEBRUARY 2022 • VOL 375 ISSUE 6580 science.org SCIENCE

CREDITS (FROM LEFT TO RIGHT: UNIVERSAL HISTORY ARCHIVE/UNIVERSAL IMAGES GROUP/GETTY IMAGES; ROBERT NEUBECKER

RESEARCH

IN BRIEF

509 From Science and other journals

REVIEW

512 Chemical pollution
Per- and polyfluoroalkyl substances
in the environment M. G. Evich et al.
REVIEW SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABG

RESEARCH ARTICLES

513 Immunology
CRISPR activation and interference
screens decode stimulation responses
in primary human T cells
R. Schmidt et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABJ

514 Plant science

Natural history–guided omics

reveals plant defensive chemistry

against leafhopper pests

Y. B a i et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABM

515 Molecular biology

Critical assessment of DNA adenine

methylation in eukaryotes using

quantitative deconvolution

Y. Kong et al.

PERSPECTIVE p. 494

522 Neurogenomics

Discovery of genomic loci of the human

cerebral cortex using genetically

informed brain atlases

C. Makowski et al.

528 Quantum gases

Second sound attenuation near

quantum criticality

X. Li et al.

533 Emerging computing

Reconfigurable perovskite nickelate

electronics for artificial intelligence

H.-T. Zhang et al.

PERSPECTIVE p. 495

540 HIV

A highly virulent variant of HIV-

circulating in the Netherlands

C. Wymant et al.

PERSPECTIVE p. 493

REPORTS

545 Organic chemistry

Diversification of aliphatic C–H bonds

in small molecules and polyolefins

through radical chain transfer

T. J. Fazekas et al.

551 Materials science

Multiscale engineered artificial

tooth enamel H. Zhao et al.

557 Greenhouse gases

Global assessment of oil and gas

methane ultra-emitters

T. Lauvaux et al.

PERSPECTIVE p. 490

562 Atmospheric chemistry

Nocturnal survival of isoprene

linked to formation of upper

tropospheric organic aerosol

P. I. Palmer et al.

566 Gene regulation

Genome organization controls transcriptional

dynamics during development

P. J. Batut et al.

PERSPECTIVE p. 491

570 Neuroscience

Probing subthreshold dynamics of hippocampal

neurons by pulsed optogenetics

M. Va l e ro et al.

574 Development

Establishment of mouse stem cells that

can recapitulate the developmental potential

of primitive endoderm Y. Ohinata et al.

ON THE COVER

An Empoasca leafhopper feeds on a

wild tobacco plant (Nicotiana attenuata).

Leafhopper pests select host plants by detect-

ing consequences of jasmonate signaling,

a hormonal signaling cascade elicited in

response to physical disturbances. By studying

recombinant inbred lines of tobacco plants

in their native habitat,

researchers have identi-

fied chemistry created

by the union of volatile

and nonvolatile defenses

in leaves that bolsters

plants’ resistance to leaf-

hoppers. See page 514.

Photo: Danny Kessler

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CONTENTS

DEPARTMENTS

473 Editorial

Science needs affirmative action

By H. Holden Thorp

582 Working Life

More than an exam By Gabriela Lopez

New Products .............................................

Science Careers ........................................ 580

LETTERS

506 Particle toxicity’s role in air pollution
By G. D. Thurston et al.

506 Response
By B. Gu et al.

507 The protein-folding problem:
Not yet solved
By P. B. Moore et al.

504

582

Banca do Antfer

Telegram: https://t.me/bancadoantfer

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