Biological Physics: Energy, Information, Life

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1.4. How to do better on exams (and discover new physical laws)[[Student version, December 8, 2002]] 15



  • Often when we forge such a link we find that powerful theoretical tools to solve one
    problem have already been created in the context of another. An example will be
    the mathematical solution of the helix-coil transition model in Chapter 9.

  • Similarly, we get to carry over powerful existingexperimentaltechniques as well. For
    example, the realization that DNA and proteins were molecules led Max Perutz,
    Linus Pauling, Maurice Wilkins and others to study their structure using X-ray
    diffraction, a technique invented to find the structure of simple, nonliving crystals
    like quartz.

  • Finally, perceiving a link between two circles of ideas can lead us toask new questions
    which later prove to be key. For example, even after Watson and Crick’s discovery
    that the DNA molecule was a very long sentence written in an alphabet with four
    letters (see Chapter 3), attention did not focus at once on the importance of finding
    the dictionary, or code, relating sequences of those letters to the 20-letter alphabet of
    amino acids constituting proteins. Thinking about the problem as one in information
    transfer led George Gamow, a physicist interested in biology, to write an influential
    paper in 1954 asking this question and suggesting that answering it might not be so
    difficult as it at first seemed.
    It may seem that we need no longer content ourselves with simple models. Can’t massive
    computers now follow the fine details of any process? Yes and no. Many low-level processes can in
    fact now be followed in molecular detail. But in practice, our ability to get a detailed picture of even
    simple systems is surprisingly limited, in part by the rapid increase of computational complexity
    when we study large numbers of particles. Surprisingly, though, many physical systems have simple
    “emergent properties” not visible in the complex dynamics of their individual molecules. The
    simple equations we’ll study seek to encapsulate these properties, and often manage to capture the
    important features of the whole complex system. Examples in this book will include the powerful
    property of hydrodynamic scale invariance to be explored in Chapter 5, the mean-field behavior
    of ions in Chapter 7, and the simple elasticity theory of complex macromolecules in Chapter 9.
    The need to exploit such simplicity and regularity in the collective behavior of many similar actors
    becomes even more acute when we begin to study even larger systems than the ones discussed in
    this book.


1.4 How to do better on exams (and discover new physical laws)


Equation 1.2 and the discussion below it made use of some simple ideas involving units. Students
often see units, and the associated ideas ofdimensional analysis,presented with a brush-your-teeth
attitude. This is regrettable. Dimensional analysis is more than just hygiene. It’s ashortcut to
insight.


1.4.1 Dimensions and units


Every physical quantity has abstractdimensionsthat tell uswhat kind of thingit is. Every kind
of dimension can be measured using a variety of differentunits.The choice of units is arbitrary.

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