Science - USA (2022-02-11)

An important feature of our reaction is the versatility of the introduced boronic ester group, which can be readily functionaliz ...

meta-arylated phenols ( 9 and 10 ) (fig. S2). Synthesis ofmeta-substituted phenols is not trivial, and there are no efficient di ...

C. Kaes, A. Katz, M. W. Hosseini,Chem. Rev. 100 , 3553– 3590 (2000). I. A. I. Mkhalid, J. H. Barnard, T. B. Marder, J. M. Murph ...

is equivocal—despite decades of investigation, decisive evidence for a causal role of sexually antagonistic loci on recombinatio ...

mutations as a result of selective interference. Fitness declines faster for larger inversions because of stronger selective int ...

as it involves the rare stabilization of a handful of inversions and is highly variable (fig.S4).However,itworksfasterinlarger p ...

CORONAVIRUS COVID mortality in India: National survey data and health facility deaths Prabhat Jha^1 *, Yashwant Deshmukh^2 , Chi ...

weekly, drawn from ~4000 local electoral areas in the whole of the country, providing a rolling 7-day average of COVID symptoms ...

reporting a 230% increase and Kerala a 37% increase. In Andhra Pradesh, which had rea- sonablyhighcoverageofexpectedruraldeaths ...

for the survey, use of three data sources, and robust metrics that document increased deaths versus earlier years or expected de ...

A. Malani, S. Ramachandran,“Using Household Rosters from Survey Data to Estimate All-cause Mortality during COVID in India”(202 ...

measures of TDEE using doubly labeled water together with changes in body composition ( 11 ). This study established that in fre ...

therefore investigated thymic function at base- line and after 2 years of sustained CR in middle- aged healthy CALERIE participa ...

674 11 FEBRUARY 2022¥VOL 375 ISSUE 6581 science.orgSCIENCE A URAD ARHGDIG ANKDD1A KRT5 TNMDCES1 SPARCASAH1 CLU P2RX6 CA3 FRG1−DT ...

SCIENCEscience.org 11 FEBRUARY 2022¥VOL 375 ISSUE 6581 675 A C D I FG J Chow HFD B H E pla2g7+/+ pla2g7-/- HFD IL1β Casp1 Nlrp3 ...

676 11 FEBRUARY 2022¥VOL 375 ISSUE 6581 science.orgSCIENCE A B C K WT Pla2g7 KO 0 2 4 6 8 10 ASC speck % of containing ASC cells ...

chemokine 11 (CCL11, also called eotaxin). Figure 4A). Furthermore, agedPla2g7−/−mice displayed decreased gene expression of IL- ...

CORONAVIRUS Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccineÐelicited human sera Alexander Muik^1 , Bonny Gaby Lui^ ...

median 256 days after dose two), neutralizing titers against the Wuhan pseudovirus were considerably reduced (GMT of 13), wherea ...

(GMT of 106 versus 368). Twenty-seven of 28 post–dose three serum specimens neutralized live SARS-CoV-2 Omicron (table S5). The ...