682 11 FEBRUARY 2022¥VOL 375 ISSUE 6581 science.orgSCIENCE
Fig. 1. Spatial-CUT&Tag: design and validation.(A) Schematic workflow. (BtoD) Comparison of unique fragments, FRiP, and mitochondrial reads between
our spatial method and other nonspatial methods. OB, olfactory bulb. (E) H&E-stained image from an adjacent tissue section of E11 mouse embryo and a
region of interest for spatial mapping. (FandG) Spatial distribution (F) and UMAP (G) of unsupervised clustering analysis. (H) Projection of ENCODE ChIP-seq
data onto the spatial-CUT&Tag embedding.
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