SCIENCE science.org 11 FEBRUARY 2022 • VOL 375 ISSUE 6581 627-C
RESEARCHselecting for dosage compensa-
tion and sexually antagonistic
regulatory effects. This sexual
antagonism protects inversions
from reestablishment of recom-
bination. Thus, expansion of the
non-recombining region of sex
chromosomes, instrumental in
the progressive degeneration of
the Y chromosome, does not rely
on the recruitment of sexually
antagonistic genes. —LMZ
Science, abj1813, this issue p. 663;
see also abn7410, p. 616
VIRAL DISEASES
Ebola virus:
Hiding in plain sight
The host-pathogen determinants
of Ebola virus (EBOV) persis-
tence and recurring disease
in immune-privileged organs,
including any association with
standard-of-care monoclonal
antibody–based treatments,
remain to be elucidated. Liu et al.
report frequent EBOV persis-
tence in the brain ventricular
system of nonhuman primates
that survived acute disease after
monoclonal antibody–based
treatment. Viral persistence was
associated with lethal recru-
descence of disease, including
severe inflammation in the brain.
These findings have implications
for long-term follow-up efforts
to reduce the individual (disease
relapse/recrudescence) and
public health (reignition of out-
breaks) consequences of viral
persistence in survivors of EBOV
infection. —OMS
Sci. Transl. Med. 14 , eabi5229 (2022).
C A N C E R I M M U N O L O G Y
Trouble in the tumor
for young T cells
Aging is associated with a
decline in adaptive immune
responses, but the impact of
young age, particularly on immu-
nity against pediatric tumors, is
not well understood. Moustaki
et al. used major histocompat-
ibility complex class I–deficient
tumors to demonstrate that,
compared with adult mice, the
young tumor microenviron-
ment promotes hyperactivation
and terminal differentiation of
tumor-specific CD8+ T cells.
Both migratory dendritic cells in
lymph nodes and tumor-engulf-
ing myeloid cells were more
mature and efficient at present-
ing antigen to CD8+ T cells.
Despite low mutation rates, solid
tumors from pediatric tumors
also contained a pool of antigen-
experienced T cells, which
correlated with the frequency
of PD-L1hi myeloid cells. These
results highlight distinct features
of younger tumor microenviron-
ments that could contribute to
age-associated differences in
tumor immunity and immuno-
therapy responses. —CO
Sci. Immunol. 7 , eabf6136 (2022).