The plant widely grows in tropical regions having an average minimum temperature
of 14°C. Mountain slopes in the humid tropical areas with well distributed annual rainfall of
1500 - 1950mm are ideal for its cultivation. Well drained virgin and fertile forest soils with
pH 4.5-6.5 are best suited for its growth. It does not tolerate waterlogging. Cinchona is
propagated through seeds and vegetative means. Most of the commercial plantations are
raised by seeds. Vegetative techniques such as grafting, budding and softwood cuttings are
employed in countries like India, Sri Lanka, Java and Guatemala. Cinchona succirubra is
commonly used as root stock in the case of grafting and budding. Hormonal treatment induces
better rooting. Seedlings are first raised in nursery under shade. Raised seedbeds of
convenient size are prepared, well decomposed compost or manure is applied , seeds are
broadcasted uniformly at 2g/m^2 , covered with a thin layer of sand and irrigated. Seeds
germinate in 10-20 days. Seedlings are transplanted into polythene bags after 3 months.
These can be transplanted into the field after 1 year at 1-2m spacing. Trees are thinned after
third year for extracting bark , leaving 50% of the trees at the end of the fifth year. The crop is
damaged by a number of fungal diseases like damping of caused by Rhizoctoria solani, tip
blight by Phytophthora parasatica, collar rot by Sclerotiun rolfsii, root rot by
Phytophthora cinnamomi, Armillaria mellea and Pythium vexans. Field sanitation, seed
treatment with organo mercurial fungicide, burning of infected plant parts and spraying 1%
Bordeaux mixture are recommended for the control of the diseases (Crandall, 1954).
Harvesting can be done in one or two phases. In one case, the complete tree is uprooted, after
8 - 10 years when the alkaloid yield is maximum. In another case, the tree is cut about 30cm
from the ground for bark after 6-7 years so that fresh sprouts come up from the stem to yield a
second crop which is harvested with the under ground roots after 6-7 years. Both the stem and
root are cut into convenient pieces, bark is separated, dried in shade, graded, packed and
traded. Bark yield is 9000-16000kg/ha (Husain, 1993).
Properties and activity
Over 35 alkaloids have been isolated from Cinchona bark, the most important among
them are quinine, quinidine, cinchonine, cinchonidine, cinchophyllamine and
idocinchophyllamine. There is considerable variation in alkaloid content ranging from 4% to
20%. However, 6-8% yield is obtained from commercial plantations. The non alkaloidal
constituents present in the bark are bitter glycosides, α-quinovin, cinchofulvic, cinchotannic
and quinic acids, a bitter essential oil possessing the odour of the bark and a red coloring
matter. The seed contains 6.13% fixed oil. Quinine and its derivatives are bitter, astringent,
acrid, thermogenic, febrifuge, oxytocic, anodyne, anti-bacterial, anthelmintic, digestive,
depurative, constipating, anti pyretic, cardiotonic, antiinflammatory, expectorant and
calcifacient (Warrier et al, 1994; Bhakuni and Jain, 1995).