The Essentials of Biostatistics for Physicians, Nurses, and Clinicians

(Ann) #1
180 Solutions to Selected Exercises


  1. Explain how the percentile method bootstrap confi dence interval for a param-
    eter is obtained.
    To obtain a percentile method bootstrap confi dence interval with confi dence
    level 100(1 − α )%, generate many (e.g., 1000) bootstrap samples. Calculate the
    estimate of interest for each bootstrap sample. Order the estimates from lowest to
    highest. Find the fi rst integer greater than or equal to 100 α /2. Let ’ s call that m.
    Then look for the m th bootstrap estimate, call it E()m. Then fi nd the fi rst integer
    greater than 100(1 − α /2). Call that integer ml. Find the ml th bootstrap estimate in
    the ordered list and call that E()
    ml. Then the interval [ E()m, E()ml] is a two - sided
    100(1 − α ) % bootstrap percentile confi dence interval for the parameter being
    estimated.

  2. The mean weight of 100 men in a particular heart study is 61 kg, with a
    standard deviation of 7.9 kg. Construct a 95% confi dence interval for the
    mean.
    We assume that the 100 men constitute a random sample of size 100, and that the
    central limit theorem will apply to the average weight. So fi rst we compute
    the Z - statistic for the lower and upper bounds of the 95% confi dence interval. Call
    the confi dence interval [ L , U ], then for the Z - scores the interval is [( L − 61)/7.9,
    ( U − 61)/7.9]. To make this a symmetric two - sided interval, we want ( L − 61)/7.9
    to be the 2.5 percentile of a standard normal random variable and ( U − 61)/7.9 to
    be the 97.5 percentile. From our table for the standard normal, we look for the
    point X with area from 0 to X equal to 0.975/2 = 0.4875. We see that this gives a
    value of X = 2.24. So ( U − 61)/7.9 = 2.24. By symmetry, ( L − 61)/7.9 = − 2.24. We
    can now solve for U and L. U = 2.24(7.9) + 6 1 = 17.696 + 6 1 = 78.696 and L =
    61 − 2.24(7.9) = 6 1 − 17.696 = 43.304.


Chapter 6


  1. How are equivalence tests different from standard hypothesis tests?
    The standard Neyman – Pearson method for hypothesis testing make the hypothesis
    of no signifi cant difference the null hypothesis with the power of the test controlled
    for the alternative by the necessary sample size. However, in equivalence testing,
    we want no signifi cant difference to be the alternative. Some people call this
    “ proving the null hypothesis. ” In the Neyman – Pearson approach, we cannot “ prove
    the null hypothesis ” without formally making it the alternative. That is because the
    type I error is only the probability that we reject the null hypothesis when the null
    hypothesis is “ true. ” It does not control the probability of accepting the null
    hypothesis when the null hypothesis is “ true. ” If the sample size is small, it is hard
    to reject the null hypothesis regardless of whether or not it is “ true. ” So to control
    that probability, we make the null hypothesis the alternative and then controlling
    the power of the test controls the probability of accepting the hypothesis when it
    is “ true, ” since that is precisely the defi nition of power. By no signifi cant difference
    we mean that the difference between the two groups is in absolute value less than
    a defi ned margin of equivalence δ.


bboth.indd 180oth.indd 180 6 6/15/2011 4:08:22 PM/ 15 / 2011 4 : 08 : 22 PM

Free download pdf