INSIGHTS
PERSPECTIVES
714 Optimizing Amazonian
dams for nature
Algorithms assess opportunities, forgone
benefits, and environmental trade-offs
By G. W. Holtgrieve and M. E. Arias
RESEARCH ARTICLE p. 753715 Repairing the blood-brain barrier
Engineered Wnt ligands specifically target
blood-brain barrier function
By A. P. McMahon and J. K. Ichida
RESEARCH ARTICLE p. 737708 Europe proposes drastic cut of
endocrine disruptor in plastic
Food safety agency adopts cautious approach
in calling for 100,000-fold cut in allowable
exposure to bisphenol A By E. Stokstad
PERSPECTIVE P. 720; RESEARCH ARTICLE p. 735709 Microbiome data dominated
by wealthy countries
Skew could hamper development
of targeted therapies By R. Pérez OrtegaFEATURES
710 The calorie counter
Evolutionary anthropologist Herman Pontzer
busts myths about how humans burn
calories—and why By A. Gibbons696 18 FEBRUARY 2022 • VOL 375 ISSUE 6582 science.org SCIENCE
PHOTO: JUSTIN COOKNEWS
IN BRIEF
700 News at a glance
IN DEPTH
703 Scientists call ‘endemic’
message premature
As pandemic restrictions lift, virus
tracking and preparation for
next variant may suffer By K. Servick
704 Transgenic fish invades
Brazilian streams
Fluorescent aquarium curiosity has
escaped from fish farms and
may threaten local biodiversity
By S. Moutinho
705 Machine builds druglike
molecules in a snap
Automated assembly of 3D molecules
could revolutionize drug discovery
By R. F. Service
706 COVID-19 boosts risk of heart
disease 1 year later
Giant study shows even mild cases can
take a long-term toll on heart and blood vessels
By M. Wadman
707 Lasting impact of infection
extends to the brain
By M. Wadman
PODCAST
717 Global growth of earthquake
early warning
Public-private partnerships provide a
method for vastly expanding sensor networks
By R. M. Allen and M. Stogaitis719 Surprising superconductivity
of graphene
An ordinary graphene bilayer exhibits
extraordinary superconductivity
By T. T. Heikkilä
REPORT p. 774720 Human health effects
of chemical mixtures
Child neurodevelopment can be adversely
affected by endocrine-disrupting chemicals
By Z. Liew and P. Guo
NEWS STORY p. 708; RESEARCH ARTICLE p. 735721 How does a lizard shed its tail?
Hierarchical microstructures help a lizard self-
amputate its tail when needed By A. Ghatak
REPORT p. 770723 Richard Leakey (1944—2022)
Renowned conservationist and advocate for
African scientists By P. KahumbuPOLICY FORUM
724 Sovereignty, sanctions, and data
sharing under international law
Pathogen samples and scientific data are
bargaining chips in a global argument about
who gets what in a pandemic
By M. Rourke et al.18 FEBRUARY 2022
VOLUME 375
ISSUE 6582CONTENTS
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