Poller B, Gutmann H, Kra ̈henbu ̈hl S, Weksler B, Romero I, Couraud PO, Tuffin G, Drewe J,
Huwyler J (2008) The human brain endothelial cell line hCMEC/D3 as a human blood-brain
barrier model for drug transport studies. J Neurochem 107:1358–1368
Pollmeier M, Toulemonde C, Fleishman C, Hanson PD (2006) Clinical evaluation of firocoxib and
carprofen for the treatment of dogs with osteoarthritis. Vet Rec 159:547–551
Polson AM, Southard GL, Dunn RL, Yewey GL, Godowski KC, Polson AP, Fulfs JC, Laster L
(1996) Periodontal pocket treatment in beagle dogs using subgingival doxycycline from a
biodegradable system. I. Initial clinical responses. J Periodontol 67:1176–1184
Pulido MM, Molina AJ, Merino G, Mendoza G, Prieto JG, Alvarez AI (2006) Interaction of
enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids
and role in milk secretion in sheep. J Vet Pharmacol Ther 29:279–287
Quinn T, O’Mahony R, Baird AW, Drudy D, Whyte P, Fanning S (2006) Multi-drug resistance in
Salmonella enterica: efflux mechanisms and their relationships with the development of
chromosomal resistance gene clusters. Curr Drug Targets 7:849–860
Rathbone MJ, Martinez MN (2002) Modified release drug delivery in veterinary medicine. Drug
Discov Today 7:823–829
Rathbone MR, Macmillan KL, Bunt CR, Burggraaf S (1997) Conceptual and commercially
available intravaginal veterinary drug delivery systems. Adv Drug Deliv Rev 28:363–392
Rathbone MJ, Kinder JE, Fike K, Kojima F, Clopton D, Ogle CR, Bunt CR (2001) Recent advances
in bovine reproductive endocrinology and physiology and their impact on drug delivery system
design for the control of the estrous cycle in cattle. Adv Drug Deliv Rev 50:277–320
Rathbone MJ, Bunt CR, Ogle CR, Burggraaf S, Macmillan KL, Pickering K (2002) Development
of an injection molded poly(epsilon-caprolactone) intravaginal insert for the delivery of
progesterone to cattle. J Control Release 85:61–71
Rebelatto MC, Guimond P, Bowersock TL, HogenEsch H (2001) Induction of systemic and
mucosal immune response in cattle by intranasal administration of pig serum albumin in
alginate microparticles. Vet Immunol Immunopathol 83:93–105
Rehbein S, Batty AF, Barth D, Visser M, Timms BJ, Barrick RA, Eagleson JS (1998) Efficacy of
an ivermectin controlled release capsule against nematode and arthropod endoparasites in
sheep. Vet Rec 142:331–334
Rehbein S, Visser M, Yoon S, Marley SE (2007) Efficacy of a combination ivermectin/prazi-
quantel paste against nematodes, cestodes and bots in naturally infected ponies. Vet Rec
161:722–724
Riviere J (2007) The future of veterinary therapeutics: a glimpse towards 2030. Vet J 174:462–471
Riviere J, Brooks JD (2009) Determination of the effective dermal penetration barrier pH of
porcine skin. J Vet Pharmacol (In Press) DOI: 10.1111/j.1365-2885.2008.01055.x
Riviere JE, Papich MG (2001) Potential and problems of developing transdermal patches for
veterinary applications. Adv Drug Deliv Rev 50:175–203
Roberts LM, Black DS, Raman C, Woodford K, Zhou M, Haggerty JE, Yan AT, Cwirla SE,
Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier
and blood-cerebral-spinal fluid barrier byin vivobiotinylation. Neuroscience 155:423–438
Rossi J (2006) Implanting beef cattle. University of Georgia Cooperative Extension.http://pubs.
caes.uga.edu/caespubs/pubcd/B1302.htm. Accessed January, 2009
Rothenberg SE, Sackman JE, Numerof RE (2009) Breaking out of the blockbuster model in animal
health. Animal Pharm (World Animal Health and Nutrition News) 652:5–7
Rothen-Weinhold A, Gurney R, Dahn M (2000) Formulation and technology aspects of controlled
drug delivery in animals. Pharm Sci Technol Today 3:222–231
Roulet A, Puel O, Gesta S, Lepage JF, Drag M, Soll M, Alvinerie M, Pineau T (2003) MDR1-
deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin.
Eur J Pharmacol 460:85–91
Rozanski EA, Bach JF, Shaw SP (2007) Advances in respiratory therapy. Vet Clin North Am
Small Anim Pract 37:963–974
110 D.J. Brayden et al.