Comparative and Veterinary Pharmacology

Table 7

In vitro susceptibility of bovine respiratory disease pathogens to antimicrobial agents

Organism

MIC

90

*(

mg/mL)

Ceftiofur Amoxicillin/

clavulanic acid(2/1)

Tilmicosin Tulathromycin Oxytetracycline Florfenicol Trimethoprim/

sulfamethoxazole(1/19)

Enrofloxacin

Mannheimia

haemolytica



0.015 0.12/0.06

4

2



16

2

0.25/4.8

0.03–0.06

Pasteurella

multocida



0.004 0.32/0.16

16

1

16

0.5

0.12/2.4



0.016–0.125

Histophilus somni

0.03

0.06/0.03

8

4

4

0.25

0.06/1.2

0.03–0.06

Mycoplasma bovis

––

>

128

>

64

32

16

• 
  

0.5

*Minimum drug concentration required for the inhibition of 90% of isolatesSources

: Aarestrup et al. (2004); Ayling et al. (2000); Godinho (2008); Godinho et al. (2005a); Kehrenberg et al. (2004); Priebe and Schwarz (2003);

Rosenbusch et al. (2005); Salmon et al. (1996); Schwarz et al. (2004)

Population Medicine and Control of Epidemics 129