For domestic species, about 400 of the 6,000 identified breeds are of economic
relevance for meat, milk, and egg production.
Dogs were the first animal species to be domesticated and subsequently they
have been selectively bred for thousands of years. This has resulted in a wide
variety of more than 400 breeds worldwide with differing anatomical, physiologi-
cal, and behavioural traits. Consequently, it can be inappropriate to generalise PK
and PD drug properties to “the dog”. For example, certain dog breeds carry a
mutation in the ATP-binding cassette (ABC) gene ABCB1, encoding for the efflux
transporter P-glycoprotein (PgP). This results in impairment in the barrier function
of the blood–brain barrier with the result that these animals are more sensitive to
adromedary(^170) camel
768 1024
1
19
1370 cameliadae rabbit
1
800
suidae cetartiodactyla
pig leporidae
cat
956
equidiae
Horse
felidae
dog
Donkey
55
40
200
170
perissodactyla carnivora canidae
Family Order
Mules
10
Muscovy
b
goose
duck duck1 100
295
anatidae
anseriformes
16 600
Quail
Chicken
Pheasant
Family Order
turkey 277
MAMMALIA
AVES
Fig. 1(a,b): Species of veterinary interest with the worldwide size ( 106 )
22 P.-L. Toutain et al.