Drug Delivery Systems in Domestic Animal
Species
David J. Brayden, Emilie J. M. Oudot, and Alan W. Baird
Contents
1 Introduction to Veterinary Drug Delivery: Comparison
with Drug Delivery in Human Medicine ................................................... 80
2 Controlled-Release Principles in Veterinary Medicine .................................... 82
3 Exogenous Regulation: Devices and Formulations ........................................ 83
3.1 Oral Formulations .................................................................... 83
3.2 Airway Delivery: Pulmonary and Nasal ............................................. 86
3.3 Topical Formulations and Transdermal Patches ..................................... 88
3.4 Intravaginal Delivery for Fertility Regulation ....................................... 91
3.5 Intramammary Formulations for Ruminants ......................................... 92
3.6 Ocular and Periodontal Adhesives ................................................... 94
3.7 Sustained-Release Parenteral Veterinary Drug Delivery ............................. 95
4 Endogenous Regulation: The Role of Drug Transporters in Regulating Delivery ......... 97
4.1 ABC Efflux Transporters in Veterinary Medicine ................................... 98
4.2 Potential Veterinary Drug Interactions Based on Transporters ..................... 100
5 Conclusions ............................................................................... 103
References .................................................................................... 104
AbstractDelivery of biologically active agents to animals is often perceived to be
the poor relation of human drug delivery. Yet this field has a long and successful
history of species-specific device and formulation development, ranging from
simple approaches and devices used in production animals to more sophisticated
formulations and approaches for a wide range of species. While several technolo-
gies using biodegradable polymers have been successfully marketed in a range of
veterinary and human products, the transfer of delivery technologies has not been
similarly applied across species. This may be due to a combination of specific
technical requirements for use of devices in different species, inter-species
D.J. Brayden (*), E.J.M. Oudot, and A.W. Baird
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin (UCD)
and UCD Conway Institute, Belfield, Dublin 4, Ireland
e-mail: [email protected]; [email protected]; [email protected]
F. Cunningham et al. (eds.),Comparative and Veterinary Pharmacology,
Handbook of Experimental Pharmacology 199,
DOI 10.1007/978-3-642-10324-7_4,#Springer-Verlag Berlin Heidelberg 2010
79