140
methamphetamine,
medication for glaucoma.
beta blockers, and
tranquilizers.SIDE EFFECTS
Melatonin is classified by the FDA as “generally regarded as safe” in recommended
doses for short-term use.
The most common side effect is gastric distress.
There is controversy about the effect of melatonin on seizure disorders. In the absence
of better science, consultation with the health care professional providing care for an
existing seizure disorder is essential if considering using melatonin.
Mood changes have been reported, both highs and lows, and even psychotic symptoms
such as hallucinations and paranoia. Persons with major depression or psychotic
disorders should consult with the health care professional providing care for the
underlying disorder before using melatonin.
Given the lack of experimental data concerning melatonin supplementation in children,
Mischoulon and Rosenbaum caution that melatonin treatment in children should be
used only “very conservatively," when the benefits of melatonin treatment clearly
outweigh any possible risks. There are no data concerning use during pregnancy or
breastfeeding.
Overconsumption of melatonin can have significant risks. It has been suggested that
millions of Americans currently consume melatonin in excessive quantities, elevating
their melatonin levels many times over those that occur normally. The notion that
uncontrolled use of melatonin is completely safe rests on little research and on the
common public experience of lack of significant short-term toxic effects. However,
disruption of the delicate mechanism of the circadian system is, in and of itself, a
significant potential side effect.