156
- RESEARCH: Long-term outcomes -- benefits and liabilities from continuing treatment with
melatonin and comparative assessment with other drugs -- require further investigation, as
do the systematic tracking, reporting and quantification of adverse effects. Sleep laboratory
studies are essential to understanding melatonin’s effect on quality of sleep.
1
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Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome,” Psychosomatic
Medicine 63(1):40-48 (2001).
(^2) Zhdanova, I. V., Wurtman, R.J., Regan, M. M., Taylor, J. A., Shi, J. P., & Leclair, O. U., “Melatonin Treatment for
Age-related Insomnia,” Journal of Clinical Endocrinology and Metabolism 86(10):4727-4730 (2001).
(^3) How to Use Herbs, Nutrients & Yoga in Mental Health Care, by Richard P. Brown, M.D. (of Columbia University
College of Physicians and Surgeons), Patricia L. Gerbarg, M.D. (of New York Medical College), and Philip R. Muskin,
M.D. (of Columbia as well) (W. W. Norton and Company, New York, 2009), at 117.
(^4) Weil, A., Spontaneous Happiness (Little, Brown and Company, New York 2011), at 97
(^5) Mischoulon & Rosenbaum, op. cit. at 186.
(^6) Id.
(^7) Asayama, K., Yamadera, H., Ito, T., Suzuki, H., Kudo, Y., & Endo, S., “Double Blind Study of Melatonin Effects on
Sleep-wake Rhythm , Cognitive and Non-cognitive Functions in Alzheimer Type Dementia” Journal of the Nippon
Medical School 70(4):334-341 (2003).
(^8) Mischoulon & Rosenbaum, op. cit. at 186.
(^9) Brown et al., op cit. at 118.
(^10) Id. at 119.
(^11) Id. at 272- 273
(^12) Id. at 121.
(^13) Mischoulon & Rosenbaum, op. cit. at 145.
(^14) Zhdanova, I. V. & Friedman, L., “Therapeutic Potential of Melatonin in Sleep and Circadian Disorders,” in Natural
Medications for Psychiatric Disorders: Considering the Alternatives, co-edited by David Mischoulon, M.D. and
Jerrold F. Rosenbaum, M.D. (both of Harvard Medical School) (Lippincott, Williams and Wilkins, Philadelphia
2002/2008), at 150.
(^15) Brown et al., op cit. at 117.
(^16) Id.
(^17) Weil, op. cit. at 97.