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likely effect is indigestion, best addressed by taking omega-3s (or fish) with other food and,
when taking supplements, taking smaller doses at different times of day rather than taking it all
at once. Given the side effects and the likely benefits, the use of omega-3s in pregnancy and
breastfeeding and in young children seems reasonable.
Drug Interactions/Contaminants
Anticoagulants, like aspirin, warfarin, or heparin may interact to increase the risk of
bleeding, though clinical evidence does not confirm this.
Blood pressure medication may need to be adjusted.
Contaminants may include mercury, PCBs, and dioxins in predatory fish (predatory fish
include tuna, salmon, perch, pike, and swordfish).Vegetarians, Vegans, and Plant Sources
Vegetarian and vegan diets are almost always very low in omega-3s, since fish oil is the most
efficient way to obtain omega-3s. Some plant-based supplements are available, but they
generally are low in the essential omega-3 elements, EPA and DHA. This requires taking a lot of
capsules to get a therapeutic dose.
CONCLUSION
Promising, but not yet proven. A diet rich in small, non-predatory fish — typically about 2
meals a week — is good for almost everyone. Use of a diet rich in non-predatory fish or fish oil
may prevent or moderate both depression or bipolar disorder and may be effective in
stabilizing mood and enhancing the effectiveness of conventional anti-depressants. Although
the evidence is preliminary, omega-3s may also serve as a neuroprotectant. Other uses being
studied may encourage use of omega-3s pending development of evidence to the contrary.
FISH IS BEST
Fish oil and other supplements supply omega-3s. But fish also contains vitamins, minerals,
other fats, and other substances that may work with the omega-3s to protect the heart and