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ST. JOHN’S WORT FOR MILD TO MODERATE DEPRESSION
SUMMARY
WHAT WE KNOW
One of the most well-known and studied CAM treatments, St. John’s wort is widely used
throughout the U.S. and Europe to treat mild to moderate depression.
MENTAL HEALTH IMPLICATIONS
Eight sources agree: St. John’s wort can help with mild to moderate depression.
It is used extensively by prescription in Germany, where randomized studies have shown the
proprietary Schwabe St. John’s wort formula to be effective in moderate to severe depression.
Mischoulon and Rosenbaum suggest that it may be a promising practice for severe depression.
Although many people use St. John’s wort as long-term treatment, there is little evidence of
long-term safety or efficacy. All of the clinical studies have been short (24-26 weeks at the
most), and most have been small.
Another source (Brown et al). notes that St. John’s wort also can be a useful treatment for
somatoform disorder (somatization disorder and hypochondria) and seasonal affective
disorder.
SIDE EFFECTS & DRUG INTERACTIONS
If you are considering continuing the use of St. John’s wort with psychotropic drugs, you should
definitely consult with the prescribing physician. People with complex medical conditions
should insist on careful monitoring while taking St. John’s wort.
Side Effects
May trigger “cycling” in people with bipolar disorder.