S-ADENOSYL-L-METHIONINE (SAM-E) FOR DEPRESSION AND TO
ENHANCE THE EFFECTIVENESS OF CONVENTIONAL ANTI-
DEPRESSANTS AND AS A POSSIBLE NEUROPROTECTANT
SUMMARY
WHAT WE KNOW
S-adenosyl-L-methionine (commonly called “SAM-e”) is a naturally-occurring chemical
component present in all cells of the body where it is essential in more than 200 metabolic
pathways. SAM-e has been approved as a prescription drug for depression in Germany, Italy,
Spain, and Russia, and has been in use in Europe for over three decades. It is available without a
prescription in the United States and some other countries.
MENTAL HEALTH IMPLICATIONS
SAM-e appears to be an effective treatment for depression: Five of seven sources agree, and
the two others say it’s promising. SAM-e can be used alone or in conjunction with other
antidepressants. Since its side effects are less than those of many antidepressants, SAM-e is
better tolerated by many people: It works more rapidly and does not cause weight gain, sexual
dysfunction, sedation, or cognitive interference. One leading researcher (Brown et al.) calls
SAM-e a “first line CAM treatment” for mild, moderate, or even severe depression.
Recent studies have shown promising potential for treatment of dementia, but those studies
are preliminary and small. Experts have suggested that SAM-e may also help address ADHD.
SIDE EFFECTS
There are few side effects of SAM-e.
It is better tolerated than other antidepressants by older people and by people on