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(^11) Chan, A., Paskavitz, J., Remington, R., Rasmussen, S. & Shea, T.B., “Efficacy of a Vitamin/nutriceutical
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(^12) The best-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein
that, when cleaved by both gamma and beta secretase, produces a short amino acid peptide called amyloid
beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains
of Alzheimer's disease patients.
(^13) Id. at 577.
(^14) Id. at 579.
(^15) Remington, R., Chan, A., Paskavitz, J. & Shea, T.B., op. cit.
(^16) Pubmed abstract, http://www.ncbi.nlm.nih.gov/pubmed/19056706
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(^19) Shekim, WO., Antun, F., Hanna, G.L., McCracken, J.T. & Hess, E.B., “S-adenosyl-L-methionine (SAM) in Adults
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(^20) Brown, R.P. & Gerbarg, P.L., Non-Drug Treatments for ADHD (W.W. Norton and Company, New York 2012), at
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(^21) How to Use Herbs, Nutrients & Yoga in Mental Health Care, by Richard P. Brown, M.D. (of Columbia University
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(^22) Torta, R., Zanalda, F., Rocca, P., et al., “Inhibitory Activity of S-adenosyl-L-methionine on Serum Gamma-
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(^23) Brown et al., op cit., at 27. Accord, Muskin, P.R., Gerbarg, P.L., and Brown, R.P., op. cit. (“Brown et al. II”) at 9.