SSRIs. Despite these evidentiary concerns, 5 - HTP has been used clinically for over 30 years for
the treatment of a wide variety of conditions, including:
fibromyalgia,
insomnia,
binge eating associated with obesity,
cerebellar ataxia, and
chronic headaches.There is some risk, but it appears to be manageable.
DRUG INTERACTIONS
Interaction with psychotropic drugs has been tested and appears generally safe, but no
reported studies have been conducted with SSRIs. Thus, consumers should consult with the
prescribing physician before using 5-HTP if they are currently being treated with a psychotropic
drug, especially an SSRI.
SIDE EFFECTS
The most common reported adverse effects are gastrointestinal, including nausea, vomiting,
and diarrhea. Sedation is also a concern. These side effects are usually moderate and often
abate or disappear once a steady dosage is achieved. Less common side effects may include
headache, insomnia, and palpitations. Studies have shown no sign of toxicity. Generally, oral 5-
HTP has been well tolerated. 5 - HTP has not been studied in children or in pregnant or breast-
feeding women. Accordingly, although there are no contraindications, it cannot be
recommended.
CONTAMINATION
Contaminated tryptophan caused an epidemic of eosinophilia-myalgia syndrome (EMS) that
peaked in 1989. One researcher cautions that absent testing, tryptophan cannot be presumed
to be safe, but others advise that while prescription tryptophan is now safe, consumers should
be careful about purchasing non-prescription tryptophan. Thus, there is some risk of