not. Brown et al. cite a 2002 randomized, controlled study which showed improvement
only on the “psychic factor” on the Hamilton Anxiety Scale.^8 The abstract concluded:
“Although the principal analysis (HAM-A between group comparison) found negative
results, the preliminary data obtained in the present study suggest that the
valepotriates may have a potential anxiolytic effect on the psychic symptoms of
anxiety.”
There is not enough scientific evidence to determine whether valerian works for other
suggested conditions, such as headaches, depression, menopausal symptoms, sedation,
irregular heartbeat and trembling.
The Natural Standard is quite negative about the use of valerian for “anxiety disorder,
depression, menopausal symptoms and sedation,” qualifying all as “C,” “unclear
scientific evidence for this use.”
- DRUG INTERACTIONS:
The Natural Standard cautions that valerian may increase the amount of drowsiness
brought on by other drugs, although it cautions, "this is an area of controversy."
Examples include benzodiazepines and other tranquilizers such as lorazepam (Ativan) or
diazepam (Valium), barbiturates such as phenobarbital, narcotics such as codeine, some
antidepressants, and alcohol. In one human study, a combination of valerian and the
beta blocker drug propranolol (Inderal) reduced concentration levels more than valerian
alone. Agitation, anxiety and self injury were reported in one consumer who took
valerian with fluoxetine (Prozac) for a mood disorder. The person was also drinking
alcohol, so causality is difficult to assign. In theory, valerian may also interact with anti-
seizure medications, although there are no human data to that effect. Valerian may also
increase the amount of drowsiness caused by some herbs or supplements, including St.
John's wort and kava.
Berkeley Wellness specifically counsels that valerian not be taken with alcohol,
tranquilizers or barbiturates. Valerian interacts with anesthetics and so must be
discontinued before surgery.
