CDP CHOLINE AS A POSSIBLE NEUROPROTECTANT
SUMMARY
WHAT WE KNOW
Citicoline, also known as cytidine diphosphate-choline (CDP Choline) and cytidine 5'-
diphosphocholine, is a psychostimulant/nootropic. It is a natural constituent of brain chemistry.
It has been used for several years outside the United States to treat cerebrovascular disorders
(those that affect the blood in the brain), including stroke, and has been studied for use in
cognitive impairment and dementia.
MENTAL HEALTH IMPLICATIONS
The studied mental health uses of CDP Choline are almost exclusively for neuroprotection. One
source and one meta-analysis (by the Cochrane Stroke Review Group), have found evidence
that supports CDP Choline’s effectiveness as a neuroprotectant. A recent well-designed Italian
study confirms its effectiveness in treating vascular dementia. The other sources do not
mention it. One study looked for an effect on attention but couldn’t find one.
SIDE EFFECTS & DRUG INTERACTIONS
There are no reported side effects or drug interactions with CDP Choline. The risk is minimal.
CONCLUSION
CDP choline may be effective only in treating vascular dementia, but it is a promising
neuroprotectant for that purpose.