CHROMIUM FOR ATYPICAL DEPRESSION
SUMMARY
WHAT WE KNOW
Although the studies are mixed, two of the three sources that mention chromium affirm its
antidepressant activity in atypical depression, a condition characterized by increased appetite,
hyperphagia (excessive hunger and abnormally large intake of solids by mouth), and
carbohydrate craving, among other clinical features. The third source judges chromium
treatment to be promising. No source dissents. Leading researchers (Lake and Spiegel) posit a
therapeutic effect in other kinds of depression as well, but the studies are not yet adequate to
fully credit this suggestion.
The risk is minimal.
DRUG INTERACTIONS
Chromium use should be coordinated with the prescribing physician of any
immunosuppressive drug.
Since chromium may lower insulin resistance, people taking oral drugs for diabetes or
using insulin should closely monitor their insulin levels while using chromium.
People taking beta-blockers may experience higher HDL cholesterol levels and increases
in blood pressure while using chromium.SIDE EFFECTS
According to the Natural Standard, chromium “appears to be well tolerated with rare or
uncommon adverse effects.”