The Natural Standard warns that since chromium may modify serotonin function in the
brain, it may interact with prescription antidepressants such as sertraline (Zoloft) and
fluoxetine (Prozac). The Natural Standard makes no reference to clinical evidence, and
Brown and Gerbarg have never observed such an interaction.
Immunosuppressive drugs are also warned against as a potential harmful interaction by
the Natural Standard, based on “some evidence” that chromium, in combination with
copper, may suppress the immune system. The Natural Standard urges caution to
people with compromised immune systems, while acknowledging that, “the evidence
thus far has not been conclusive.” Chromium use should be coordinated with the
prescribing physician of any immunosuppressive drug.
Since chromium may lower insulin-resistance, people taking oral drugs for diabetes or
using insulin should monitor themselves carefully while using chromium.
People taking beta-blockers may experience higher HDL cholesterol levels and increases
in blood pressure while using chromium.
Drugs that may decrease chromium levels include esomeprazole (Nexium/Prilosec),
ranitidine (Zantac), antacids, corticosteroids, aspirin and NSAIDs.
- SIDE EFFECTS:
According to the Natural Standard, chromium “appears to be well tolerated with rare
or uncommon adverse effects.” This position applies only to the trivalent form of
chromium, as the hexavalent form appears to be toxic. The principal side effects cited by
the Natural Standard are stomach discomfort, nausea and vomiting. “Very rarely,” skin
rashes, insomnia, headache, mood changes, muscle damage, or anemia may occur. The
Natural Standard says only that “it is possible” that chromium may lower blood sugar,
and this concern is only relevant if the person is taking diabetes medicine. The Natural
Standard details less likely side effects, including adverse effects on the heart, blood,
kidneys, or liver, and cognitive, perceptual and motor effects.
Iovieno et al. found chromium supplements to be well tolerated and safe. However,
they reported different “commonly reported side effects” with chromium
