DHEA AND 7-KETO DHEA FOR DEPRESSION AND BIPOLAR DISORDER
SUMMARY
DHEA (5-Dehydroepiandrosterone) is a natural steroid produced in the adrenal glands, the
gonads and the brain. It is the most abundant circulating steroid in humans. A form of DHEA, 7 -
keto DHEA (3-acetyl- 7 - oxodehydroepiandosterone), is claimed to have fewer side effects.
WHAT WE KNOW
DHEA is involved in a range of biological effects and may cause some problematic
hormonal side effects. The newer form (7-keto DHEA) may be safer, but research on its
effectiveness and its side effects is extremely limited.
DHEA supplementation may help with depression, but it has a long list of potential side
effects and drug interactions. MHA cautions against use of DHEA, cautiously
recommends 7-keto DHEA as an alternative to DHEA pending further testing, and
counsels getting the help of a skilled health care practitioner, especially if using any
other drugs or herbs.MENTAL HEALTH IMPLICATIONS
Mood Disorders
Only two of the four sources that discuss DHEA are unambiguous in supporting its use for
treatment of depression. Most sources do not mention DHEA for depression. All sources advise
caution because of the risks.
Bipolar Disorder
DHEA should be used with caution and in lower doses in people with bipolar disorder. DHEA
may exacerbate mania, irritability and aggression. Leading researchers (Mischoulon and
Rosenbaum) recommend that people taking DHEA should be regularly monitored for occasional
development of aggressive or disinhibited behavior.