but the studies are inconsistent, and causation cannot be inferred. A chart of the 17
most prominent hypotheses serves to illustrate the disagreement.^3
Results from the criticized trials were mixed, and some cast doubt on the efficacy of
DHEA. A “well-controlled” 2006 trial examined the effects of DHEA on well-being and
found no discernible effect over placebo in women or in men over a two-year trial
period.^4
Nonetheless, Mischoulon and Rosenbaum summarize that “beneficial effects on mood
are consistently reported” in people with depression using DHEA.
On balance, Mischoulon and Rosenbaum conclude that: “...DHEA administration
CANNOT BE RECOMMENDED for clinical use at this time....[T]he full risk-benefit ratio,
especially with high-dose treatment or with treatment for extended periods of time,
remains uncertain.”^5
The Natural Standard states there is “sufficient evidence” supporting use of DHEA,
but only for depression, ranking the evidence as “B,” “good scientific evidence for this
use,” and adding that the “majority” of clinical studies support this use.
DISSENT: The Mayo Clinic takes a strong position against use of DHEA, giving it a red
rating, but its discussion is less absolute: “Studies suggest that DHEA may be effective
in treating mild depression....[but] long-term use and high levels may cause serious side
effects.” “DHEA may be useful in treating depression ..., but strictly under the
guidance of a specialist.”
DHEA is not recommended for children or during pregnancy or breast-feeding.
- SUGGESTED BUT UNPROVEN USES: PTSD: The five case reports by Brown and Sageman are
the only published reports concerning use of 7-keto DHEA for PTSD, but the results are very
promising.^6 Clinical studies on 7-keto DHEA are rare, and a follow-up study is needed to
substantiate the work of Sageman and Brown.
- SUGGESTED BUT UNPROVEN USES: SCHIZOPHRENIA: Brown et al. suggest that because
lower DHEA levels correlate with higher psychopathology, DHEA supplementation could
