and clopidogrel (Plavix). Similarly, coenzyme Q10 or ginseng may increase the risk of
clotting when used with DHEA According to the Natural Standard, hormone replacement therapy and birth control
pills “should not be combined with DHEA unless under medical supervision.” For the
same reason, people taking herbs that have hormonal effects such as alfalfa, black
cohosh and blood root should be careful about potential additive effects.
DHEA may alter heart rate or rhythms and should be used cautiously with heart
medications or drugs that may also affect heart rhythms. For the same reason, caution is
advised in the use of herbs that may alter heart rhythms, including adonis, balloon
cotton, and foxglove (digitalis). Alcohol may increase these effects of DHEA.
There are some reports that drugs such as canrenoate, anastrozole (Arimidex), growth
hormones, methyephenidale, amlodipine, nicardipine and other calcium channel
blockers such as diltiazem (Cardizem) and aprazolem (Xanax) may increase DHEA levels
within the body, which could lead to increased side effects when combined with DHEA
supplements. Chromium may have the same effect.
DHEA may interact with psychotropic drugs such as clozapine (Clozaril). Other
psychotropic drugs are not mentioned, but DHEA use should be discussed with the
prescribing physician.
DHEA may interact with GABA-receptor drugs used for seizures or pain. DHEA may
increase the effectiveness of methadone. DHEA may add to the effects of clofibrate or
contribute to tamoxifen resistance in breast cancer.
DHEA use may result in decreased rate of development of antibodies after influenza
vaccination.
Drugs that reduce normal levels of DHEA produced by the body include dopamine,
insulin, corticosteroids, drugs used to treat endometriosis such as danazol, opiate
painkillers, antipsychotics, and drugs containing estrogen. Many other interactions are
possible.
Since no source including the Natural Standard discusses 7-keto DHEA, there is no
scientific assessment of any differential drug interaction. This requires more study.