90
reducing depressive and other symptoms in people with depression and alcoholism.The risk is minimal.
MENTAL HEALTH IMPLICATIONS
Depression
Folate is a promising stand-alone and adjunctive treatment for depression. Supplementation of
folate deficiencies is recommended by five sources and only disavowed by one, the Natural
Standard, and adjunctive treatment of depression with folate is a promising practice, especially
for women, even if folate levels are not low. Although the Natural Standard concedes that
folate has been used adjunctively, for enhancing treatment response to antidepressants, it does
not credit the evidence in its rating. Two of the sources counsel supplementation even in the
absence of folate deficiency, and while one leading researcher (Bottiglieri) does not explicitly
concur with that recommendation, his description of the research would place him in the same
camp. Another leading researcher (Mischoulon) does not view folate supplementation as
effective in people with normal folate levels.
Neuroprotection
Researchers have observed some potential positive effects of folate and other B vitamins (B6
and B12 in addition to B9) on the aging brain, , but folate supplementation appears to be a
promising practice only for mild cognitive impairment. Like ginkgo biloba (see that topic), it may
not help prevent or treat dementia. Still, almost everyone should be sure to eat lots of leafy
green vegetables (and fortified grains, if they are well tolerated)--especially as they get older
and their appetites decrease and maladies multiply. And B vitamin supplements are a prudent
neuroprotectant.
SIDE EFFECTS & DRUG INTERACTIONS
Aside from allergic reactions, folate and B vitamins are generally quite safe. However, the
Natural Standard lists many medical conditions that may require folate supplementation and
possible prescription drug interactions which should be considered by prescribing physicians.