DRUG/HERB INTERACTIONS GUIDE STROPHANTHUS /I-187Strophanthus
(Simultaneous administration with
herb enhance both effects and side
effects)
Strophanthus Gratus
(Simultaneous administration with
herb enhance both effects and side
effects)
SAW PALMETTO
Alpha Adrenergic Blockers
(Saw Palmetto has an additive
alpha adrenergic blocking effect
when given in combination with
alpha blockers)
Androgens
(Saw Palmetto antagonizes the
effect of androgens)
SCOPOLIA
Amantadine Hydrochloride
(Increased effect when given
simultaneously with herb)
Quinidine
(Increased effect when given
simultaneously with herb)
Tricyclic Antidepressants
(Increased effect when given
simultaneously with herb)
SCOPOLIA CARNIOLICA
(See under Scopolia)
SCOTCH BROOM
MAO Inhibitors
(Increased risk of hypertensive
crisis)
SELECTIVE SEROTONIN REUPTAKE
INHIBITORS
St. John's Wort
(Concomitant use with the herb
will result in an additive serotonin
effect and possible toxicity)
SENNA
Antiarrhythmics
(Senna-induced hypokalemia may
increase risk of arrythmia)
Digitalis Glycoside Preparations
(Senna-induced hypokalemia may
increase toxicity of digitalis
preparations)
Estrogen
(Senna decreases estrogen levels
when taken with estrogen
supplements) I
Indomethacin
(Decreased therapeutic effect of
Senna)
Nifedipine
(Inhibits activity of Senna via
calcium channel blockade)
SERENOA REPENS
(See under Saw Palmetto)
SIL YBUM MARIANUM
(See under Milk Thistle)
SQUILL
Calcium
(Increases effectiveness and side
effects of herb)
Digoxin
(Squill potentiates the positive
inotropic and negative chronopic
effects of digoxin)
Glucocorticoids
(Increases effectiveness and side
effects of herb)
Laxatives
(Increases effectiveness and side
effects of herb)
Methylxanthines
(Increases risk of cardiac
arrhythmias)
Phosphodiesterase Inhibitors
(Increases risk of cardiac
arrhythmias)
Quinidine
(Increases risk of cardiac
arrhythmias; increases
effectiveness and side effects of
herb)
Saluretics
(Increases effectiveness and side
effects of herb)
Sympathomimetic Agents
(Increases risk of cardiac
arrhythmias)
ST. JOHN'S WORT
Cyclosporine
(The herb induces the cytochrome
P450 enzyme system and will
lower cyclosporine serum levels)
Digoxin
(Co-administration of the herb
with digoxin has resulted in a
significant decrease in the digoxin
area under the curve)Indinavir Sulfate
(The herb induces the cytochrome
P450 enzyme system and will
lower indinavir serum levels)
Oral Contraceptives
(Breakthrough bleeding has been
reported with concomitant use of
the herb with oral contraceptives)
Photosensitizing Agents
(An additive photosensitizing
effect is expected when the herb
is used with photosensitizing
drugs such as tetracyclines,
sulfonamides, and thiazides)
Reserpine
(Hypericum antagonizes the effect
of reserpine)
Selective Serotonin Reuptake
Inhibitors
(Concomitant use with the herb
will result in an additive serotonin
effect and possible toxicity)
Sympathomimetic Agents
(St. John's Wort may have MAO
inhibitor properties and caution
should be used with
sympathomimetic agents)
Theophylline
(The herb induces the cytochrome
P450 enzyme system and will
lower theophylline serum levels)STROPHANTHUS
Calcium Salts
(Simultaneous administration with
herb enhance both effects and side
effects)
Glucocorticoids
(Simultaneous administration with
herb enhance both effects and side
effects)
Laxatives
(Simultaneous administration with
herb enhance both effects and side
effects)
Quinidine
(Simultaneous administration with
herb enhance both effects and side
effects)
Saluretics «
(Simultaneous administration with
herb enhance both effects and side
effects)