PDR for Herbal Medicines

HERBAL MONOGRAPHS

BILBERRY FRUIT

No health hazards or side effects are known in conjunction

with the proper administration of designated therapeutic

dosages.

^ OVERDOSAGE

BILBERRY LEAF

The signs of poisoning observed in animal experiments

(including cachexia, anemia, icterus) appeared only in

conjunction with the chronic administration of high dosages

and are presumably effects of the tannins.

DOSAGE

BILBERRY LEAF

Preparation: To prepare an infusion, pour boiling water over

1 g finely cut drug (1 teaspoonful = approximately 0.6g) and

strain after 10 to 15 minutes. Not to be taken over a long

duration.

Daily Dosage: The daily dosage of tea is 1 cup 2 to 3 times

daily. For an infusion, a single dose is equal to 1 g per cup.

BILBERRY FRUIT

Mode of Administration: Tablets, capsules, macerated drug

^ for infusions for internal use and local application.

How Supplied:

Most commercially available capsules and tablets are stand-

ardized at 25 to 36% anthocyanoside content.

Capsule — 40 mg, 60 mg, 80 mg, 125 mg, 160 mg, 310 mg,

400 mg, 500 mg, 1000 mg

Tablet — 40 mg

Preparation: To prepare an infusion, use 5 to 10 g mashed

drug in cold water, bring to a simmer for 10 minutes, then

strain (1 teaspoonful = 4 g drug). A 10% decoction is

prepared for external use.

Daily Dose: 20 to 60 g of unprocessed fruit for internal use.

Externally use a 10% infusion. For commercially available

tablets and capsules that are standardized to 36% anthocya-

nosides, the recommended dose is 60 to 160 mg three times

daily.

LITERATURE
m* BILBERRY LEAF
Bertuglia S, Malandrino S.Colantuoni A Effect of Vaccinium
myrtillus anthocyanosides on ischaemia reperfusion injury in
hamster cheek pouch microcirculation. Pharmacol Res, 84:183-7,
Mar-Apr, 1995.
Bettini V et al., (1984) Fitoterapia 55(6):323.
Bettini V et al., (1985) Fitoterapia 56(1):3.
Bomser J et al., In vitro anticancer activity of fruit extracts
from Vaccinium species. In: PM 62(3):212-216. 1996.

BILBERRY/77

Bosio E et al., Ginkgo biloba L. and Vaccinium myrtillus L.

extracts prevent photo-induced oxidation of low density

lipoproteins. In: PM 62, Abstracts of the 44m Ann Congress of

GA, 24. 1996.

Cignarella A, Bertozzi D, Pinna C, Puglisi L, Hypolipidemic

activity of Vaccinium myrtillus leaves on an model of

genetically hyperlipidemic rat. In: PM 58(Suppl. 7):A581. 1992.

Colantuoni A, Bertuglia S, Magistretti MJ, Donato L Effects of

Vaccinium Myrtillus anthocyanosides on arterial vasomotion.

Arzneimittelforschung, 84:905-9, Sep, 1991.

Dombrowicz E, Zadernowski R, Swiatek L Phenolic acids in

leaves of Arctostaphylos uva ursi L. Vaccinium vitis idaea L.

and Vaccinium myrtillus L. Pharmazie, 84:680-1, Sep, 1991.

Frohne D, Vaccinium myrtillus L.- Die Heidelbeere. In: ZPT

11(6):209-211. 1999.

Kyerematen G, Sandberg F, (1986) Acta Pharm Suec. 23:101.

Sticher O et al., (1979) Planta Med 35:253.

Further information in:

Hansel R, Keller K, Rimpler H, Schneider G (Hrsg.), Hagers

Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6

(Drogen): Springer Verlag Berlin, Heidelberg, New York, 1992-

1994.

Madaus G, Lehrbuch der Biologischen Arzneimittel, Bde 1-3,

Nachdruck, Georg Olms Verlag Hildesheim 1979.

Roth L, Daunderer M, Kormann K, Giftpflanzen, Pflanzengifte,

4. Aufl., Ecomed Fachverlag Landsberg Lech 1993.
   Teuscher E, Biogene Arzneimittel, 5. Aufl., Wiss. Verlagsges.
   Stuttgart 1997.
   Wichtl M (Hrsg.), Teedrogen, 4. Aufl., Wiss. Verlagsges.
   Stuttgart 1997.
   BILBERRY FRUIT
   Bertuglia S, et al. Effect of Vacciniu myrtillus anthocyanosides
   on ischaema reperfusion injury in hamster cheek pouch
   microcirculation. Pharmaol Res:31; 183-187. 1995.
   Bettini V et al., (1984) Fitoterapia 55(6):323.
   Bettini V et al., (1985) Fitoterapia 56(1 ):3.
   Bomser J et al., In vitro anticancer activity of fruit extracts
   from Vaccinium species. In: PM 62(3):212-216. 1996.
   Boniface R & Robert AM: Influence of anthocyanosides on
   human connective tissue metabolism. Klin Monatsbl
   Augenheilkd 209(6):368-372. 1996.
   Bosio E et al., Ginkgo biloba L. and Vaccinium myrtillus L.
   extracts prevent photo-induced oxidation of low density
   lipoproteins. In: PM 62, Abstracts of the 44th Ann Congress of
   GA, 24. 1996.
   Cignarella A, Bertozzi D, Pinna C, Puglisi L, Hypolipidemic
   activity of Vaccinium myrtillus leaves on an model of
   genetically hyperlipidemic rat. In: PM 58(Suppl. 7):A581. 1992.
   Frohne D, Vaccinium myrtillus L.- Die Heidelbeere. In: ZPT
   11(6):209-211. 1999.
   Kyerematen G, Sandberg F, (1986) Acta Pharm Suec 23:101.