HERBAL MONOGRAPHSVolatile oil (0.1%)EFFECTS
Bugle weed has antigonadotropic and antithyrotropic effects.
It inhibits the peripheral de-iodination of T4. The phenolic
constituents of the drug have an atigonadotropic effect. They
"^ cause a lowering of the prolactin level and have a depressant
effect on the thyroid as a result of an inhibition of iodine
transport and the release of preformed thyroid hormone.INDICATIONS AND USAGE
Approved by Commission E:- Nervousness and insomnia
- Premenstrual syndrome (PMS)
Unproven Uses: Bugleweed is used for mild thyroid
hyperfunction associated with disturbances of the autonomic
nervous system. It is also used for tension and pain in the
breast (mastodynia). In folk medicine, it is used for
functional and organic cardiac conditions, liver and kidney
disease.Homeopathic Uses: Lycopus virginicus is used to treat
hyperthyroidism in homeopathic preparations.
* w
CONTRAINDICATIONS
The drug is contraindicated in hypofunction of the thyroid
and thyroid gland enlargement without function disturbance.
There should not be any simultaneous administration of
thyroid hormone preparations.
PRECAUTIONS AND ADVERSE REACTIONS
General: No health hazards or side effects are known in
conjunction with the proper administration of designated
therapeutic dosages.Drug Interactions: No simultaneous administration of thy-
roid preparations. Administration of Lycopus preparations
disturbs the administration of diagnostic procedures with
radioactive isotopes.OVERDOSAGE
Enlargement of the diyroid gland is possible only through
administration of the drug in very high dosage. Sudden
discontinuation of Lycopus preparation can lead to a rebound
phenomenon with increased TSH secretion and prolactin
£» secretion, as well as an increase of the hyperthyroid
symptom complex and mastodynia.
DOSAGE
Mode of Administration: Comminuted herb, freshly pressed
juice and other galenic preparations for internal use.Daily Dosage: The average daily dose is 1 to 2 gm of the
drug for teas, and water-ethanol extracts containing the
equivalent of 20 mg of the drug.BUGLEWEED/127Each patient has his own individual optimal level qf thyroid
hormone. Only rough estimations of dosage are possible for
thyroid disorders, in which age and weight must be
considered.Homeopathic Dosage: 5 drops, 1 tablet or 10 globules every
30 to 60 minutes (acute) or 1 to 3 times daily (chronic);
parenterally: 1 to 2 ml sc acute, 3 times daily; chronic: once
a day (HAB1)LITERATURE
Aufmkolk M, (1985) Endocrinology 116(5):1687.Bucar R et al., Flavonoid glycosides from Lycopus europaeus.
In: PM 6I(5):489. 1995.Frombling-Borges A, (1987) Intrathyreoidale Wirkung von
Lycopus europaeus, Pflanzensauren, Tyrosinen, Thyroninen und
Lithiumchlorid. Darstellung einer Schilddrusensekretions-
blockade. Inauguraldissertation. Westfalische Wilhelms-
Universtitiit Munster.Frombling-Borges A, Intrathyreoidale Wirkung von Lycopus
europaeus, Pflanzensauren. Kaltumjodid und Lithiumchlorid. In:
ZPT 10(!):1. 1990.
Gumbinger HG et al., (1981) Contraception 23(6):661.
Hegnauer R, Kooiman P, (1978) Planta Med 33(1): 13.
Jeremic D et al.. (1985) Tetrahedron 41(2):357.John M, Gumbinger HG, Winterhoff H, The oxidation of
caffeic acid derivatives as model reaction for the formation of
potent gonadotropin inhibitors in plant extracts. In: PM
59(3): 195. 1993.Jung F, Kiesewetter H, Mrowietz C, Pindur G, Heiden M,
Miyashita C, Wenzel E, Akutwirkungen eines zusammen-
gesetzten Knoblauchpraparates auf die FliepTahigkeit des Blutes.
In: ZPT 10(3):87. 1989.
Kartnig T, Lycopus europaeus L. - Wolfsfup oder Wolfstrapp.
In: ZPT 10(1):31. 1989.
Kern W, List PH, Hdrhammer L (Hrsg.), Hagers Handbuch der
Pharmazeutischen Praxis, 4. Auf!., Bde. 1-8, Springer Verlag
Berlin, Heidelberg, New York, 1969.
Schulz R, Hansel R, Rationale Phytotherapie, Springer Verlag
Heidelberg 1996.
Kooiman P, (1972) Acta Bot Neerl 21(4)417.
Sourgens H et al., (1982) Planta Med 45:78.Teuscher E, Biogene Arzneimittel, 5. Aufl., Wiss. Verlagsges.
Stuttgart 1997.
Wagner H, Wiesenauer M, Phytotherapie. Phytopharmaka und
pflanzliche Homoopathika, Fischer-Verlag, Stuttgart, Jena, New
York 1995.