PDR for Herbal Medicines

222 /CORIANDER PDR FOR HERBAL MEDICINES

PRECAUTIONS AND ADVERSE REACTIONS

Health risks or side effects following the proper administra-

tion of designated therapeutic dosages are not recorded. The

drug possesses a weak potential for sensitization.

DOSAGE

Mode of Administration: Crushed and powdered drug, as

well as other galenic preparations for internal indication.

Preparations: Coriander extract 1:2 is prepared by percolat-

ing 1 weight part of the drug with 45% ethanol so that 2

weights tincture is produced. The infusion is prepared by

pouring 150 ml of boiling water over 2 tsp. of crushed drug

and straining after 15 minutes.

Daily Dosage: The average daily dose is 3.0 gm of drug. The

single dose is 1 gm.

Infusion — 1 fresh cup between meals.

Tincture — 10 to 20 drops after meals.

Storage: The non-comminuted drug is stored at a maximum

temperature of 25°C, protected from light in well-sealed

containers.

LITERATURE

Calcandi V. Ciropol-Calcandi I. Georgescu E, PA 16(6):331-

334. 
     
     
     
     1961. Diedreichsen A et al., Chemotypes of Coriandrum sativum L. in
           the Gatersleben Genebank. In: PM 62, Abstracts of the 44th
           Ann Congress of GA, 82. 1996.
           Formacek. Buch. In: Formacek, V, Kubeczka KH: Essential
           Oils Analysis by Capillary Gas Chromatography and Carbon-13-
           NMR Spectroscopy, John Wiley & Sons, Chicester, New York,
           Brisbane, Toronto. Singapore 1982.
           Gijbels MJM et al.. (1982) Fitoterapia 53(1/2):17.
           Ram AS, Devi HM, (1983) Indian J Bot 6(1):21.
           Schratz E, Quadry SMJS, PM 14(3):310-325. 1966.
           Further information in:
           Fenaroli's Handbook of Flavor Ingredients, Vol. 1, 2nd Ed.,
           CRC Press 1975.
           Hansel R, Keller K, Rimpler H, Schneider G (Ed), Hagers
           Handbuch der Pharmazeutischen Praxis. 5. Aufl., Bde 4-6
           (Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992-
           1994
           Leung AY, Encyclopedia of Common Natural Ingredients Used
           in Food, Drugs and Cosmetics. John Wiley & Sons Inc. New
           York 1980.
           Mascolo N et al., Phytother Res 1 (1987), 28.
           Simon JE, Chadwick AF, Craker LE (Eds.), Herbs. An Indexed
           Bibliography 1971-80. Archon Books, USA 1984.
     
     
     
     

Steinegger E, Hansel R, Pharmakognosie, 5. Aufl., Springer
Verlag Heidelberg 1992.

Teuscher E, Biogene Arzneimittel, 5. Aufl., Wiss. Verlagsges.

mbH Stuttgart 1997.

Wichtl M (Hrsg.), Teedrogen, 4. Aufl., Wiss. Verlagsges.

Stuttgart 1997.

Coriandrum sativum

See Coriander

Corn Cockle

Agrostemma githago

DESCRIPTION

Medicinal Parts: The medicinal part of the herb is the seed.

Flower and Fruit: The flowers are apical or arranged in twos

or threes like a curled cyme; the 5 sepals of the calyx have 2

to 4 cm long tips that project above the corolla; the flower

tube is 14 to 18 mm. The 5 petals are 30 to 35 mm long, dark

purple and occasionally whitish. There are 5 styles and 10

stamens. The ovary is superior, undivided and has a central

placenta. The fruit capsule is 15 to 18 mm long with

numerous 2.5 to 3.5 mm long, warty seeds.

Leaves, Stem and Root: Agrostemma githago is an annual

herb that grows upright, up to 100 cm high. The leaves are

opposite, linear-lanceolate, acuminate and up to 10 mm

wide. The stem is upright, usually unbranched, shaggy-gray-

pubescent. The primary root is spindle-shaped and heavily

branched.

Habitat: Europe and Asia

Production: Corn cockle seed is the dried seed of Agrostem-

ma githago.

Other Names: Cockle

ACTIONS AND PHARMACOLOGY

COMPOUNDS

Triterpene saponins: chief component is githagoside (0.04%,

gypsogenine tetraglycoside), additional components are gyp-

sogenin and quillaic acid gylcosides

Fatty oil: 6%

Steroids: sterols, including alpha-spinasterol

Unusual amino acids: orcyl alanine (0.4%)

EFFECTS

The drug exhibits an antimycotic effect. Cornflower seeds

are toxic in higher dosages.