PDR for Herbal Medicines

352/GLOBE FLOWER PDR FOR HERBAL MEDICINES

PRECAUTIONS AND ADVERSE REACTIONS

No health hazards or side effects are known in conjunction

with the proper administration of designated therapeutic

dosages. Extended skin contact with the freshly harvested,

bruised plant can lead to blisters and cauterizations due to

the resulting protoanemonine formation, which is severely

irritating to skin and mucous membranes.

If taken internally, severe irritation to the gastrointestinal

tract, combined with colic and diarrhea, as well as irritation

of the urinary drainage passages, are possible. Because of the

very low level of protoanemonine-forming substances in the

plant, the danger of poisoning is quite low.

DOSAGE

Mode of Administration: The drug is obsolete.

LITERATURE

Kern W, List PH, Horhammer L (Hrsg.). Hagers Handbuch der

Pharmazeutischen Praxis, 4. Aufl., Bde. 1-8: Springer Verlag

Berlin, Heidelberg, New York, 1969.

Roth L, Daunderer M, Kormann K, Giftpflanzen, Pflanzengifte.

4. Aufl.. Ecomed Fachverlag Landsberg Lech 1993.

Glycine soja

See Soybean

Glycyrrhiza glabra

See Licorice

Gnaphalium uliginosum

See Cudweed

Goa Powder

Andira araroba

DESCRIPTION

Medicinal Parts: The medicinal part is the dried and

pulverized latex of the trunk and branches.

Flower and Fruit: Andira araroba is a large smooth tree
whose yellowish wood has vertically running channels and
spaces. The latex collects increasingly in these spaces as the
tree ages. The bark forms in long flat pieces about 3 mm
thick and is grayish-white and fissured externally. The inner

surface is brownish and striated. The fracture is laminated

with yellow fibers.

Characteristics: The taste is mucilaginous and bitter, and the

odor is slight but disagreeable.

Habitat: The tree grows in Brazil.

Production: Goa powder is exuded from the nuclear cavity

of Andira araroba. The exuded substance is purified by

recrystalization in benzol, thus producing raw chrysarobin.

Other Names: Araroba, Bahia Powder, Brazil Powder,

Chrysatobine, Crude Chrysarobin, Ringworm Powder

ACTIONS AND PHARMACOLOGY

COMPOUNDS

Anthrone derivatives: in particular chrysophanolanthrone,

dehydroemodine anthrone monomethyl ether, emodine an-

throne monomethyl ether, dimerics of these compounds

EFFECTS

The powder is a strong reducing agent. It causes severe

erythema upon contact with the skin. It inhibits glucose-6-

phosphate-dehydrogenization in psoriatic skin conditions.

The drug easily absorbs through the skin.

INDICATIONS AND USAGE

Unproven Uses: Goa Powder is used for psoriasis in

chrysarobin ointments and for various kinds of dermatomy-

cosis. It has been widely replaced by synthetic anthranol,

which is also used in the treatment of psoriasis.

PRECAUTIONS AND ADVERSE REACTIONS

The drug is severely irritating to skin and mucous mem-

branes (redness, swelling, pustules and conjunctivitis, even

without eye contact). Internal administration leads to vomit-

ing, diarrhea and kidney inflammation (with as little as

0.01 g). External administration on large skin areas could

cause resorptive poisonings.

DOSAGE

Mode of Administration: Goa Powder is administered

topically in emulsion form, but has largely been replaced by

the synthetic anthranol cignolin.

LITERATURE

Anonym, Abwehr von Arzneimittelrisiken, Stufe II. In: DAZ

136(38):3253-2354. 1996.

BGA, Arzneimittelrisiken: Anthranoide. In: DAZ 132(21): 1164.

1992.

Miiller K, Wiegrebe W, Psoriasis und Antipsoriatika. In: DAZ

137(22): 1893-1902. 1997.

Further information in:

Kern W, List PH, Horhammer L (Hrsg.), Hagers Handbuch der

Pharmazeutischen Praxis, 4. Aufl., Bde. 1-8, Springer Verlag

Berlin, Heidelberg, New York, 1969.