PDR for Herbal Medicines

574/PASSION FLOWER PDR FOR HERBAL MEDICINES

ACTIONS AND PHARMACOLOGY

COMPOUNDS

Flavonoids (up to 2.5%): in particular C-glycosyl-flavones,

including among others isovitexin-2"-o-glucoside, schafto-

side, isoschaftoside, isoorientin, isoorientin-2"-o-glucoside,

vicenin-2, lucenin-2

Cyanogenic glycosides: gynocardine (less than 0.1%)

Volatile oil (trace)

The frequently postulated presence of harmaline alkaloids

could not be confirmed.

EFFECTS

Passion Rower contains glycosides and in animal tests is

hypotensive and stimulates respiration. Sedative or spasmo-

lytic effects could not be definitively proven. The use of the

herb for nervous agitation, difficulty falling asleep or

nervous gastrointestinal symptoms needs further investiga-

tion. A motility-inhibiting effect has been observed in animal

tests.

INDICATIONS AND USAGE

Approved by Commission E:

• Nervousness and insomnia

Unproven Uses: Passion Flower is used internally for

depressive states such as hysteria, general nervous agitation,

insomnia and nervous gastrointestinal complaints. The herb

is used externally for hemorrhoids and as a bath additive for

nervous agitation.

Homeopathic Uses: Passifloraincamata is used for insomnia,

convulsions and agitation.

PRECAUTIONS.MMO ADVERSE REACTIONS .. ~

No health hazards or side effects are known in conjunction

with the proper administration of designated therapeutic

dosages.

DOSAGE

Mode of Administration: As a comminuted herb for tea and

other galenic preparations for internal use or as sedative bath

additives.

How Supplied:

Capsules — 400 mg

Liquid (alcohol free) — 1:1

Preparation: To make an infusion, pour 150 ml of hot water
over 1 teaspoon drug and strain after 10 minutes. To make a
rinse for the external treatment of hemorrhoids, put 20 gm
drug into 200 ml simmering water, strain and use when
cooled.

Daily Dosage:

Tea — Pour 150 ml of hot water over 1 teaspoon of the herb

and strain after 10 minutes. Drink 2 to 3 times throughout the

day and one-half hour before bedtime.

Tincture — 0.5 to 2 ml, 3 times daily.

External use — 20 gm of the herb in 200 ml simmering

water. Strain and use when cool as a wash or rinse.

Homeopathic Dosage: 5 drops, 1 tablet, 10 globules every 30

to 60 minutes (acute) or 1 to 3 times daily (chronic);

parenterally: 1 to 2 ml SC, acute: 3 times daily; chronic:

once a day; ointment: 1 to 2 times daily; 1 suppository 2 to 3

times daily (acute and chronic) (HAB1).

LITERATURE

Anon, Phytotherapeutika: Nachgewiesene Wirkung, aber

wirksame Stoffe meist nicht bekannt. In: DAZ 137(15): 1221-

1222. 
      
      
      
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            Busse WW et al., (1984) J All Clin. Immunol. 73:801.
            Caesar W, Passionsblume. Kulturhistorische Aspekte einer
            Arzneipflanze. In: DAZ 137(8): 587-93. 1997.
            Hansel R, Pflanzliche Beruhigungsmittel Moglichkeiten und
            Grenzen der Selbstmedikation. In: DAZ 135(32), 2935-2943.
      
      
      
      


1223. 
      

      Hansel R, Keller K, Rimpler H, Schneider G (Ed.), Hagers
      Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6
      (Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992-

      
      


1224. 
      

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      Passiflora edulis Aqueous Extract in Rodents and Humans.
      Phytother Res 5:262-266.
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      Arzneipflanze. Z Phytother 16:115-126.
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      Phytother 16:90-99.
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