PDR for Herbal Medicines

HERBAL MONOGRAPHS PETASITES/587

Daily Dosage: Dosing of herbal preparations is highly

dependent on a variety of factors, such as growing and

harvesting conditions, plant parts, extraction methods used

and the dosage form chosen by the manufacturer. Standard-

ization to single constituent makers has proven unreliable.

^P Since no official standards have been established to date to

regulate production of herbal medicines in the United States,

dosage ranges must be employed as guidelines.

Preparations equivalent to 4.5 to 7 gm drug may be used.

When used internally, the daily dosage must not exceed 0.1

micrograms of pyrrolizidine alkaloids with 1.2 unsaturated

necine structure including their N-oxides. When used

externally, the maximum daily dosage should not exceed 10

micrograms of pyrrolizidine alkaloids with 1.2 unsaturated

necine structure including their N-oxides. Teas should not be

used.

Homeopathic Uses: 5 drops, 1 tablet or 10 globules every 30

to 60 minutes (acute) or 1 to 3 times daily (chronic);

parenterally: 1 to 2 ml sc, acute: 3 times daily; chronic: once

a day (HAB1).

LITERATURE
PETASITES LEAF
w Bicket D et al., Identification and characterization of inhibitors
of peptide-leukotriene-synthesis from Petasites hybridus. In: PM
60(4):318. 1994.
Brune K, Analgetische Wirkung von Pestwurz. In: DAZ
133(37):3296. 1993.
Brune K, Bickel D, Peskar BA, Gastro-Protective Effects by
Extracts of Petasites hybridus: The Role of Inhibition of
Peptido-leukotriene Synthesis. In: PM 59(6):494. 1993.
Bucher K, (1951) Ober ein antispastisches Prinzip in Petasites
officinalis Moench,^Arch Exp Path Pharmacol 213:69.
Carle R, Pflanzliche Antiphlogistika und Spasmolytika. In: ZPT
9(3):67. 1988.
Chizzola R, Distribution of the pyrrolizidine alkaloids
senecionine and intergerrimine within the Petasites hybridus. In:
PM 58(7)93. 1992.
Dorsch W, Neues iiber antientzundliche Drogen. In: ZPT
14(1):26. 1993.
Frohne D, Pfander HJ, Giftpflanzen - Ein Handbuch fur
4P* Apotheker, Toxikologen und Biologen, 4. Aufl., Wiss. Verlags-
Ges. Stuttgart 1997.
Hansel R, Keller K, Rimpler H, Schneider G (Hrsg.), Hagers
Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6
(Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992-
1994.
Hasler A et al., Trace analysis of pyrrolizidine alkaloids by
GC-NPD of extracts from the roots of Petasites hybridus. In:
PM 62, Abstracts of the 44th Ann Congress of GA, 147. 1996.

Madaus G, Lehrbuch der Biologischen Arzneimittel, Bde 1-3,

Nachdruck, Georg Olms Verlag Hildesheim 1979.

Mauz Ch et al., (1985) Pharm Acta Helv 60:4.

Meier B, Die Pestwurz - Stand der Forschung. In: ZPT

15(5):268-284. 1994.

Roder E, Pyrrolizidinhaltige Arzneipflanzen. In: DAZ

132(45):2427-2435. 1992.

Roth L, Daunderer M, Kormann K, Giftpflanzen, Pflanzengifte,

4. Aufl., Ecomed Fachverlag Landsberg Lech 1993.
   Teuscher E, Lindequist U, Biogene Gifte - Biologie, Chemie,
   Pharmakologie, 2. Aufl., Fischer Verlag Stuttgart 1994.
   Wichtl M (Hrsg.), Teedrogen, 4. Aufl., Wiss. Verlagsges.
   Stuttgart 1997.
   PETASITES ROOT
   Bicket D et al.. Identification and characterization of inhibitors
   of peptide-leukotriene-synthesis from Petasites hybridus. In: PM
   60(4):318. 1994.
   Brune K, Analgetische Wirkung von Pestwurz. In: DAZ
   133(37):3296. 1993.
   Brune K, Bickel D, Peskar BA, Gastro-Protective Effects by
   Extracts of Petasites hybridus: The Role of Inhibition of
   Peptido-leukotriene Synthesis. In: PM 59(6):494. 1993.
   Bucher K, (1951) Ober ein antispastisches Prinzip in Petasites
   officinalis Moench. Arch Exp Path Pharmacol 213:69.
   Carle R, Pflanzliche Antiphlogistika und Spasmolytika. In: ZPT
   9(3):67. 1988.
   Chizzola R, Distribution of the pyrrolizidine alkaloids
   senecionine and intergerrimine within the Petasites hybridus. In:
   PM 58(7)93. 1992.
   Dorsch W, Neues iiber antientzündliche Drogen. In: ZPT
   14(1):26. 1993.
   Frohne D, Pfander HJ, Giftpflanzen - Ein Handbuch fur
   Apotheker, Toxikologen und Biologen, 4. Aufl., Wiss. Verlags-
   Ges. Stuttgart 1997.
   Gruenwald J, Brendler T, Jaenicke C (Eds.), Physicians' Desk
   Reference for Herbal Medicines. Medical Economics Company
   Inc., Montvale, 1998.
   Hansel R, Keller K, Rimpler H, Schneider G (Hrsg.), Hagers
   Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6
   (Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992-


5. 
   

   Hasler A et al., Trace analysis of pyrrolizidine alkaloids by
   GC-NPD of extracts from the roots of Petasites hybridus. In:
   PM 62, Abstracts of the 44th Ann Congress of GA, 147. 1996.
   Madaus G, Lehrbuch der Biologischen Arzneimittel, Bde 1-3,
   Nachdruck, Georg Olms Verlag Hildesheim 1979.
   Mauz Ch et al., (1985) Pharm Acta Helv 60:4.
   Meier B, Die Pestwurz - Stand der Forschung. In: ZPT
   15(5):268-284. 1994.
   Roder E, Pyrrolizidinhaltige Arzneipflanzen. In: DAZ
   132(45):2427-2435. 1992.