Leung's Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics

Regulatory Status. Regulated in the U.S. as a

dietary supplement. The root is the subject of a

German therapeutic monograph, indicated for

premenstrual discomfort and dysmenorrhea

(BLUMENTHAL1).

REFERENCES

See the General References forBAILEY1;BARNES ET AL.;BLUMENTHAL1&2;BRADLY;DER MARDEROSIAN

AND BEUTLER;FOGARTY;FOSTER;FOSTER AND DUKE;JIANGSU;KROCHMAL AND KROCHMAL;GRIEVE;MCKENNA;

MERCK;UPHOF;WREN;YOUNGKEN.

1. S. Chen et al.,J. Nat. Prod., 65 , 601
   (2002).


2. K. He et al.,Planta Med., 66 , 635 (2000).


3. E. Bedir and L. A. Khan,Chem. Pharm.
   Bull., 48 , 425 (2000).


4. K. Wende et al.,J. Nat. Prod., 64 , 986
   (2001).


5. A. Panossian et al.,Phytochem. Anal., 15 ,
   100 (2004).


6. S. O. Kruse,Planta Med., 65 , 763 (1999).


7. H. Jarry et al., Planta Med., 51 , 316
   (1985).


8. J. E. Burdette et al.,J. Agric. Food Chem.,
   51 , 5661 (2003).


9. H. Jarry et al.,Maturitas, 44 (Suppl. 1),
   S31 (2003).


10. D. Seidlova-Wuttke et al., Maturitas,
    44 (Suppl. 1), S39 (2003).


11. E. M. D€uker et al.,Planta Med., 57 , 420
    (1991).


12. L. S. Einbond et al.,Breast Cancer Res.
    Treat., 83 , 221 (2004).


13. K. Woo et al.,J. Pharmacol. Exp. Ther.,
    309 , 641 (2004).


14. H. Winterhoff et al.,Maturitas, 44 (Suppl.
    1), S51 (2003).


15. W. Wuttke et al.,Maturitas, 44 (Suppl. 1),
    S67 (2003).


16. T. Low Dog et al.,Menopause, 10 , 299
    (2003).


17. J. Freudenstein et al.,Cancer Res., 62 ,
    3448 (2002).


18. T. Nilein and J. Freudenstein,Toxicol.
    Lett. , 150 ,271 (2004).

BLACK HAW BARK

Source:Viburnum prunifoliumL. (Family

Caprifoliaceae).

Common/vernacular names:Black haw, nan-

ny bush, stag bush, viburnum.

GENERAL DESCRIPTION

Viburnum prunifoliumis a spreading decid-

uous shrub or small tree, up to 5 m high, with

blue-black fruits and white flowers native to

North America, from Connecticut to Florida

and west to Michigan and Texas.

Parts used are the root and stem barks.

CHEMICAL COMPOSITION

Viburnum prunifolium contains coumarins

(scopoletin,^1 scopolin, aesculetin), alkaloids,

b-sitosterin, arbutin, triterpenes (a-andb-

amyrin, ursolic acid, oleanolic acid), amento-

flavone,2,3and iridoid glucosides (Valeriana

type).4,5Otherconstituentsincludemalic,citric,

oxalic, and valeric acids); tannin; bitter resin;

andothers(MERCK).1-Methyl-2,3-dibutylhemi-

mellitate was isolated from the stem bark.^6

PHARMACOLOGY AND BIOLOGICAL

ACTIVITIES

Black haw has shown uterine antispasmodic

propertiesin vitro.7,8

Black haw bark 99