CHAPTER 13 Antimicrobials—Fighting Infection^213
Extended-spectrum Penicillin
Pregnancy Category: B
Route Dose Time
carbenicillin (Geocillin)
Protein-Binding: 50%
Half-Life: 1–1^1 / 2 hours
PO 0.5–1 g Every 6 hours
IV 50–83.3 mg/kg Every 4 hours
IM 50–83.3 mg/kg Every 4 hours
mezlocillin (Mezlin)
Protein-Binding: 30%–40%
Half-Life:^1 / 2 –1 hour
IV 33.3–58.3 mg/kg Every 4 hours
IM 33.3–58.3 mg/kg Every 4 hours
piperacillin (Pipracil)
Protein-Binding: 16%–22%
Half-Life: 0.6–1.5 hours
IV 3–4 g Every 4 to 6 hours
IM 3–4 g Every 4 to 6 hours
piperacillin + tazobactam (Zosyn, Tazocin)
Protein-Binding: Unknown
Half-Life: 0.7–1.2 hours
IV 3.375–4 .5 g Every 6 to 8 hours
ticarcillin (Ticar)
Pregnancy Category: C
Protein-Binding: 45%–65%
Half-Life:^1 / 2 –1^1 / 2 hours
IV 1–4 g Every 6 hours
IM 1 g Every 6 hours
ticarcillin + clavulanate (timentin)
Protein-Binding: 45%–65%
Half-Life: 1–1^1 / 2 hours
IV 33.3–50 mg Every 4 hours