CHAPTER 13 Antimicrobials—Fighting Infection^239
Fluoroquinolones
Pregnancy Category: C
Route Dose Time
Ciprofloxacin (Cipro)
Protein-Binding: 20%
Half-Life: 3–4 hours
PO 250–500 mg Every 12 hours
Fluroquinoline 500–750 mg Every 12 hours
Severe Infections
IV Mild to 400 mg Every 12 hours
Moderate Infections
Enoxacin (Penetrex)
Protein-Binding: 40%
Half-Life: 3–6 hours
PO 200-400mg Every 12 hours 1–2 weeks
Levofloxacin (Levaquin)
Protein-Binding: 50%
Half-Life: 6 hours
PO 250-750mg
IV 500 mg/d 7–14 days
Lomefloxacin (Maxaquin)
Protein-Binding: Unknown
Half-Life: 6–8 hours
PO 400 mg 10–14 days
Norfloxacin (Noroxin)
Protein-Binding: 10%–11%
Half-Life: 3–4 hours
PO 400 mg Every 12 hours for
72 hours
Ofloxacin (Floxin)
Protein-Binding: 20%
Half-Life: 5–8 hours
PO/IV 300–400 mg Every 12 hours for
10 days