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2000, p 581.11 BONE INJURY AND FRACTURE
HEALING
Carlos A Guanche, MD- Bone injury is multifactorial in its effects. The cellu-
lar content of bone, the ability of such cells to produce
extracellular matrix and the structure and organization
of the components of bone are altered.
BONE ANATOMY(RECKER, 1992)OSTEOGENICPRECURSORCELLS- Present on all nonresorbtive bone surfaces and make
up the deep layer of the periosteum and the endos-
teum. - The Periosteumis a tough vascular layer of connective
tissue. It covers the bone but not its articulating surface. - The Endosteumis a single layer of osteogenic cells
lacking a fibrous component.
OSTEOBLASTS- Mature, metabolically active bone forming cells.
a. Secrete osteoid the unmineralized matrix that sub-
sequently undergoes mineralization.
b. Some osteoblasts are converted into osteocytes,
whereas others remain on the surfaces of bone as
lining cells.
c. Play a role in the activation of bone resorption by
osteoclasts.
OSTEOCYTES- Mature osteoblasts trapped within the bone matrix.
•Form a network of cytoplasmic processes extending
through cylindrical canaliculi to blood vessels and
other osteocytes.
•Involved in extracellular calcium and phosphorus
homeostasis.