inorganic chemistry

TABLE VI

P

HOTOSENSITIZER

C

ONCENTRATION AND

L

ASER

L

IGHT

D

OSE

R

EQUIRED TO

K

ILL

90%

OF THE

C

ELLS

IN VITRO

Sensitizer*

log

P

OW

Cell lines

LD

50Dark

(m

M)

LD

90PDT

(m

M)

h

n^90

(J/cm

2 )

F

PDT

(cm

2 /J)

Photofrin

a



b 0

Epidermoid ca. (A431)

5

60

1.5

0.06

Foscan

a

5.3

Epidermoid ca. (A431)

8

0.1

1.5

53

H

BPurhep 2

c

11.2

RIF

10

1.5

10

1

H

DOHPTMB 2

d

6.8

HeLa

4

0.2

10

2

H

TCl 2

PBOH 2

e



1.7

f

Prostate (PC-3)

623

35

6

3

aFrom Refs. (

104

) and (

108

).

bFor hematoporphyrin IX in

Ref. (

108

).

cFrom Ref. (

101

); concentrations between 1.5 and 2.5

mM were tested in the dark, and it was reported that 1.5

mM solutions had no dark toxicity;

although IC

50Dark

was not reported, given the onset of dark toxicity, 10

mM is an educated guess for IC

50Dark

.

dFrom Ref. (

109

).

eFrom Ref. (

89

).

fFrom Ref. (

90

).