among men, and the risk factor was alcohol consumption. Use the
Mantel–Haenszel procedure to compare the cases versus the controls.
State your null hypothesis and choice of test size.TABLE E6.23
Daily Alcohol Consumption
Age 80 þg0–79g
25–44 Cases 5 5
Controls 35 270
45–64 Cases 67 55
Controls 56 277
65 þ Cases 24 44
Controls 18 1296.24 Postmenopausal women who develop endometrial cancer are on the
whole heavier than women who do not develop the disease. One possible
explanation is that heavy women are more exposed to endogenous
estrogens, which are produced in postmenopausal women by conversion
of steroid precursors to active estrogens in peripheral fat. In the face
of varying levels of endogenous estrogen production, one might ask
whether the carcinogenic potential of exogenous estrogens would be the
peripheral fat. In the face of varying levels of endogenous estrogen pro-
duction, one might ask whether the carcinogenic potential of exogenous
estrogens would be the same in all women. A study has been conducted
to examine the relation between weight, replacement estrogen therapy,
and endometrial cancer in a case–control study (Table E6.24). Use the
Mantel–Haenszel procedure to compare the cases versus the controls.
State your null hypothesis and choice of test size.
TABLE E6.24
Estrogen Replacement
Weight (kg) Yes No
< 57 Cases 20 12
Controls 61 183
57–75 Cases 37 45
Controls 113 378
> 75 Cases 9 42
Controls 23 1406.25 Risk factors of gallstone disease were investigated in male self-defense
o‰cials who received, between October 1986 and December 1990, a
retirement health examination at the Self-Defense Forces Fukuoka
242 COMPARISON OF POPULATION PROPORTIONS