SCIENCEscience.org 25 FEBRUARY 2022¥VOL 375 ISSUE 6583 871
Fig. 2. Substrate scope and synthetic application.(A) Substrate scope. Reactions were performed on a 0.2-mmol scale. The yields are of isolated material after
purification. The ee values were determined with high-performance liquid chromatography with the isolated products. *Ir(F-ppy) 3 instead of Ir(ppy) 3 .†(S)-1b/HOTf instead of
(S)-1a/HNTf 2 .‡The ee values were corresponding to the diastereomers as listed, respectively. §Reaction time was 2 hours. ¶CH 2 Cl 2 instead of MeCN as the solvent.
#Ir(F-ppy) 3 instead of Ir(ppy) 3. **The amount of benzoic acid was 15 mol % instead of 3 mol %. (B) Synthetic application. Reactions were performed on a 0.5-mmol scale.
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