Science - USA (2022-02-25)

Diffraction Methods in
Structural Biology

Breaking Down the Barriers in Structural Biology
into Defined, Measurable and Solvable Problems
JUL 24-29, 2022
BATES COLLEGE, LEWISTON, ME
CHAIR:James Holton
VICE CHAIR: Janet Newman

• Artificial Intelligence in Structural BiologyAirlie McCoy,
  Ho Leung Ng, Christopher Watkins


• Optimal Data Collection Limited by Damage, Equipment
  and Sample QualityAna Gonzalez, Elspeth Garman, Kunio Hirata,
  Gleb Bourenkov


• Sample Prep with Uncooperative MoleculesAlex
  McPherson, Sarah Bowman, Anchi Cheng


• Processing Algorithms for Difficult DataKay Diederichs,
  Dominika Borek, Loes Kroon-Batenburg, Derek Mendez, Jeney Wierman


• Massive Radiations: Electrons and NeutronsGarib Murshudov,
  Wah Chiu, Johan Hattne, Flora Meilleur


• Interpreting Low-Resolution Maps and Weak DataPaul
  Emsley,Tristan Croll, Jane Richardson, Isabel Uson


• Divining Ligands with ConfidenceDorothee Liebschner,
  Tom Peat, Frank von Delft


• Selected Poster PresentationsEdward Snell


• The Last Angstrom: Disorder, Dynamics and
  FunctionHelen Ginn,Andrea Thorn, Henry van den Bedem, Rozaliya
  Barabash


• The GRC Power Hour™Elspeth Garman

Diffraction Methods in

Structural Biology

Data-Rich Experiments in Serial Crystallography,

Time-Resolved Studies and MicroED

JUL 23-24, 2022

Chairs: Jennifer Wierman and James Parkhurst

DNA Topoisomerases in
Biology and Medicine

Topoisomerase Mechanism, Function and Inhibition:
From Single-Molecule Analyses to Clinical Trials
AUG 7-12, 2022
BRYANT UNIVERSITY, SMITHFIELD, RI
CHAIRS:Lynn Zechiedrich and Keir Neuman
VICE CHAIRS:Yuk-Ching Tse-Dinh and Dagmar Klostermeier

• Keynote Session: Molecular Mechanisms to Clinical
  TrialsValakunja Nagaraja,Sue Jinks-Robertson, Yves Pommier


• Topoisomerases as Targets for Antimicrobial Agents
  Marc Drolet,Alexandra Aubry, Pan Chan, Neil Osheroff


• Processing of Topoisomerase AdductsHannah Klein, Heidrun
  Interthal, Robert Van Waardenburg


• Interplay Between Genome Topology and Topoisomerase
  InteractionsDavid Levens, Erez Aiden, Laura Baranello, Konstantin
  Severinov


• Modeling DNA Topoisomerases and TopologySarah Harris,
  Davide Marenduzz, Mariel Vasquez


• Topoisomerases and DNA Topology in Cancer Chemotherapy
  Scott Kaufmann, Mary-Ann Bjornsti, Junjie Chen, Karen Vasquez


• DNA Topology and Topoisomerases at the Single Molecule
  LevelAlice Pyne, Zev Bryant, Michelle Wang


• Topoisomerases as Cellular Poisons and Essential
  EnzymesShunichi Takeda, Anna Bizard, Nayun Kim, Yuh-Hwa Wang


• Topoisomerase Structure and FunctionValerie Lamour,
  James Berger, Nei-Li Chan

DNA Topoisomerases in

Biology and Medicine

Enzymology, Cellular Functions, Roles in

Diseases and Therapeutic Targeting

A U G 6 -7, 2 0 2 2

Chairs: Amanda Riccio and Thomas Germe

Drug Carriers in Medicine

and Biology

Enabling New Therapies Through Drug Carrier Design

JUL 31-AUG 5, 2022

MOUNT SNOW, WEST DOVER, VT

CHAIRS:Suzie Pun and Samir Mitragotri

VICE CHAIRS:Kathryn Whitehead and Vadim Dudkin

• Keynote Session: Drug Carriers Revolutionizing
  Therapeutic ApproachesVladimir Muzykantov, Dennis Lee,
  Paula Hammond, David Mooney


• New Materials for Drug DeliveryEster Kwon,Paul Wender, Kristy
  Ainslie, Jianjun Cheng, Jean-Christophe Leroux


• Advances Toward Translation and Carrier Interactions with
  the Immune SystemElizabeth Nance,Jinming Gao, Anna
  Schwendeman


• Drug Carriers in OncologyRizia Bardhan,Natalie Artzi, Debra
  Auguste, Tatiana Novobrantseva, Anand Subramony


• Cell-Mediated Drug DeliveryJuliane Nguyen,Zhen Gu, Elena
  Batrakova


• Intracellular Delivery of BiologicsMichael Mitchell,Julie
  Champion, Craig Duvall, Richard Wooster


• Selected Poster PresentationsVadim Dudkin, Kathryn Whitehead


• Biological CarriersOlivia Merkel,David Schaffer, Laura Ensign, Don
  Hilvert, Nicole Steinmetz


• Overcoming Barriers to Oral DeliveryOmid Veiseh, Maria Jose
  Alonso, Sujatha Sonti, Giovanni Traverso


• The GRC Power Hour™Kristy Ainslie

Drug Carriers in Medicine and Biology

Exploring Size-Based Delivery Strategies

for Biologics and Novel Drug Cargos

JUL 30-31, 2022

Chairs: Anusha Pusuluri and Nicholas Lamson

Drug Metabolism

Drug Discovery to Precision Therapeutics:

Novel Mechanisms, Models and Technologies

JUL 10-15, 2022

HOLDERNESS SCHOOL, HOLDERNESS, NH

CHAIR:J. Steven Leeder

VICE CHAIR:Jane Kenny

• Keynote Session: Integration of Drug Metabolism Science
  and Big Data to Inform Precision MedicineJane Kenny,
  Sir Munir Pirmohamed


• Drug Transporters: Advancing Drug Development and
  Precision TherapeuticsAndrew Goodman,Nichole Klatt, Matthew
  Redinbo, Peter Turnbaugh, Michael Zimmermann


• Drugs of the Future: Probing the ADME Properties of Novel
  TherapeuticsSara Humphreys,Gaurav Bhardwaj, Diane Ramsden


• Drug Metabolism by Intestinal MicroorganismsKim
  Brouwer,Bruno Hagenbuch, Kaspar Locher, Pallabi Mitra, Gauri Rao


• New Techniques in Drug Metabolism Methodology
  Katherine Elvira,Xiaomeng Shen, Boyang Zhang


• Prediction of Drug Metabolism In Vivo from In Vitro Studies
  Cyrus Khojasteh,Leslie Benet, Murat Cirit, Hiroyuki Mizuguchi, Charity Nofziger


• Selected Poster PresentationsPatrick Murphy


• Mechanisms of Drug MetabolismEmily Scott,Xinxin Ding, Ruili
  Huang, Eric Johnson, Richard Auchus


• Harnessing Technology to Advance Individualized
  TherapeuticsNamandje Bumpus,Netz Arroyo, Catherine Fenselau,
  Manthena Varma


• The GRC Power Hour™

Drug Metabolism

Translational Models and Technologies

to Predict Drug Disposition and Response

JUL 9-10, 2022

CHAIR:Chelsea Hosey

Drug Resistance

Strategies to Disrupt Resistance in Infectious

Diseases, Cancer and Agriculture

JUN 26-JUL 1, 2022

BRYANT UNIVERSITY, SMITHFIELD, RI

CHAIRS:Lizbeth Hedstrom and Daruka Mahadevan

VICE CHAIRS:Aaron Goldman and Alexis Kaushansky

• Keynote Session: Protecting New Drugs and Pesticides
  Against ResistanceAlexis Kaushansky,Alina Baum, Seva
  Rostovtsev


• The Emergence of ResistancePradipsinh Rathod, Sophie
  Helaine, Houra Merrikh, Susan Rosenberg, Sarah Amend


• Eco-Evolutionary Strategies to Address ResistanceAndriy
  Marusyk,Eugene Shakhnovich, Jacob Scott


• Combating Resistance with Novel TargetsMithila Jugulam,
  Emily Derbyshire, Eachan Johnson, Mark Rolfe, Paul Workman


• Durable Drug DesignTimothy Wencewicz,David Epstein, Adam
  Palmer


• Systems and Modeling Strategies to Address Resistance
  Adam Palmer,Nitin Baliga, Funda Meric-Bernstam, Pamela Yeh


• Threats and ResponsesFunda Meric-Bernstam,Sarat
  Chandarlapaty, Pradipsinh Rathod


• Microbiome and ResistanceCelia Schiffer,Christopher Ford,
  Neha Garg, Yoshitomo Kikuchi, Peter Belenky


• Keynote Session: Emerging Strategies to Combat
  ResistanceAaron Goldman,Richard Alm, Paul Turner, James Welsh


• The GRC Power Hour™

Drug Resistance

Mechanisms and Approaches to

Overcoming Drug Resistance in Cancer,

Infectious Disease and Agriculture

JUN 25-26, 2022

CHAIR:Michael Lombardo

Drug Safety

Advances in Models, New Modalities and

Clinical Considerations for Drug Safety

JUN 19-24, 2022

STONEHILL COLLEGE, EASTON, MA

CHAIR:Myrtle Davis

VICE CHAIR:Ruth Roberts

• Keynote Session: Modeling Complex Biological Systems
  David Watson,Dennis Discher


• Emerging Applications of Big Data and Machine Learning
  in Safety AssessmentJames Stevens, Daniel Rudmann,Melissa
  Hallow, Laszlo Urban, Erio Barale-Thomas


• Leveraging Human Genetics and Big Data to Inform Drug
  SafetyBlanca Rodriguez,Danish Saleheen, Lucas Ward, Hao Zhu


• Biomarker Science in Drug Discovery and
  DevelopmentVishal Vaidya,Guruprasad Aithal, Holly Soares


• Microphysiological Models: Advances in Modeling
  Complex In Vivo Functions and Organ ResponsesAnthony
  Bahinski, Kyle Kolaja,Mark Donowitz, Joanna Burdette, Girija Goyal


• New Paradigms in Translational Safety ScienceLeigh Ann
  Burns Naas,Lolke Dehaan, Gary Gilmour, Michael Morton, Eric Sobie


• Novel Therapeutic Modalities: Challenges and Opportunities
  in Nonclinical Safety Assessment StrategiesWendy
  Freebern, Jeff Willy,Fiona Spence, Kathy Meyer, Padma Narayanan


• Full Utilization of the Clinical Experience in the Nonclinical
  SpaceMichelle Berny-Lang, Kelly Filipski,Bonnie Ky, Christine
  Miaskowski, Yinghong Mimi Wang


• Keynote Session: Advancing Drug Safety Through Innovation
  Ruth Roberts,Manasi Nandi


• The GRC Power Hour™Michelle Berny-Lang, Leigh Ann Burns Naas

Drug Safety

Emerging Technologies and

Strategies for Drug Safety Evaluation

JUN 18-19, 2022

CHAIRS:Lauren Lewis and Molly Morgan