V.M.D.’s work. G.S. supervised C.C.’s work. L.d.L. supervised the
entire project. S.-B.L. prepared figures and wrote the manuscript.
S.-B.L. and L.d.L. edited the manuscript, with input from other
coauthors. All authors discussed the results and commented on
the manuscript.Competing interests:L.d.L. and S.-B.L. are
co-inventors on a WIPO (World Intellectual Property Organization)
patent WO/2021/119018 related to the work described in this
manuscript. L.d.L. is a Chief Scientific Advisor to and receives
consulting fees from Attune Neurosciences. L.d.L. is a paid
consultant to Eisai Pharmaceuticals and Idorsia Pharmaceuticals.
G.S. is a cofounder of Epiodyne, a drug discovery company, an
inventor on a patent application (US application no. 62/962,581)
related to imaging of neural dynamics to discover analgesics,
and a member of the NIH PSPP (Preclinical Screening Platform for
Pain) External Consulting Board. The remaining authors declare
that they have no competing interests.Data and materials
availability:The sequencing reads and preprocessed data are
available from NCBI Gene Expression Omnibus (GSE160581). Code
is freely available on Github (https://github.com/justuskebschull/
Hyprocretin_Li2020). All other data are available in the main text or
the supplementary materials. All materials are available from
the corresponding author upon reasonable request.SUPPLEMENTARY MATERIALS
science.org/doi/10.1126/science.abh3021
Materials and Methods
Supplementary Text
Figs. S1 to S14
MDAR Reproducibility Checklist9 March 2021; accepted 14 January 2022
10.1126/science.abh3021Liet al.,Science 375 , eabh3021 (2022) 25 February 2022 14 of 14
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