100 QUESTIONS IN CARDIOLOGY

(Michael S) #1
growing experience of transcatheter device closure of such defects

which avoids the need for cardiopulmonary bypass.

In summary, the indications for closure of a ventricular septal

defect in an adult include the presence of a significant left to right

shunt in the absence of pulmonary vascular disease, progressive

aortic valve disease, recurrent endocarditis and acute post-

infarction rupture in patients with haemodynamic compromise.

Currently there is no evidence that closure of a small ventricular

septal defect would prevent the occurrence of arrhythmias and

ventricular dysfunction in the long term. The presence of

established pulmonary vascular disease (Eisenmenger syndrome)

is a contraindication to surgical intervention.

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Backer CL, Winters RC, Zales VR et al. Restrictive ventricular septal
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Benton JP, Barker KS. Transcatheter closure of ventricular septal defect: a
nonsurgical approach to the care of the patient with acute ventricular
septal rupture. Heart Lung1992; 2211 : 356–64.
Kidd L, Driscoll DJ, Gersony WM et al. Second natural history study of
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septal defects. Circulation1993; 8877 : 138–51.
Neumayer U, Stone S, Somerville J. Small ventricular septal defects in
adults. Eur Heart J1998; 1199 : 1573–82.

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