Biology of Disease

NUCLEUS AND NUCLEOCYTOPLASMIC TRANSPORT

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Cytoplasmic filament Central plug ortransporter

Cytoplasmic octomer ring

Spoke Nuclear octomer

ring

Nuclear lamina

Basket filament

Terminal ring

Lumen

Outer

membrane

Inner

membrane

Nuclear

basket

Nuclear

envelope

C)

Figure 16.1 (A) Electron micrograph showing the nuclear envelope (E), internal lamina (L), nuclear basket (B) and nuclear pore (P).
Picture by G. Szabo from Fawcett, D.W. (1981)The cell,2nd edn, W.B. Saunders, with permission. Courtesy of Professor D.W. Fawcett. (B) Electron
micrographs of the (i) outer and (ii) inner faces of nuclear pore complexes approximately 90 nm in diameter. Courtesy of Drs T.A. Allen and
M.W. Goldberg, Department of Structural Cell Biology, Paterson Institute, Manchester, UK.(C) Schematic of a nuclear pore complex.See text for
details.